Anxiety & Depression Forced Swimming Test for Screening Anti-Depressive Effects Anxiety & Depression • Forced Swimming Test key features Specifications Le804 (D x H) Le803 (D x H) Le803L (D x H) 10 x 25 cm (4 x 10 in) 20 x 50 cm (8 x 20 in) 30 x 50 cm (12 x 20 in) } Standard transparent cylinder } Available in other sizes by special order The forced swimming test is a relatively simplistic and widely used model for testing depression. The forcedswimming paradigm was originally adopted by Porsolt et al. (1978). Naïve rats and mice forced to swim in a transparent cylinder (aversive and confined environment) innately fight to escape the apparatus. Following failed attempts to escape, they become immobile (i.e. float), a behavior generally considered as despair or “depressive-like” Prior treatment . with antidepressants decreases the time spent immobile and increases the latency to reach the first immobility episode. We provide several different sized transparent cylinders for the forced swimming test. note Order # 76-0471 76-0472 76-0494 contact us for customized design. Ordering Information Model Le804 Le803 Le803L Product Small cylinder with base for fSt experiments medium cylinder with base for fSt experiments Large cylinder with base for fSt experiments note To automate the forced swim test, please also see our sMART video tracking on pages 4-7, or freezeframe software options, pages 71. 80 www.coulbourn.com • www.panlab.com