Sensory Motor & Coordination Rotameter for Evaluating Rotation Behavior Rotational behavior has proved a popular technique for screening the behavioral effects of a wide variety of lesions, drugs, and other experimental manipulations on the brain of rodents. This test is widely carried out in experiments using animal models of Parkinson’s Disease with unilateral lesions in the dopaminergic nigrostriatal system. The subject wears an adjustable harness with velcro connected to the rotation sensor by a flexible tie. Wide ranges of harnesses are available to fit different animal sizes. The subject is then placed into a transparent container (cylindrical or oval) with a lateral support for a vertical stand. A bi-directional rotation sensor provides a double (right and left turns) output with adjustable regulation of pulses/turns. Experiment duration and time intervals of measurement can be set. An external multicounter is necessary for data storage; it counts the number of partial and complete left and right turns depending of the adjustments made on the rotation sensors. key features Sensory Motor & Coordination • Rotameter for Evaluating Rotation Behavior } Rotation sensor with adjustable TTL output signal } Configuring experiment duration and time intervals of counting right turns The computer interface SEDACOM allows easy exportation of data (through RS-232 serial port) in a format compatible with Excel™. } Counting the number of partial and complete left and } Adjustable harness with soft ring (new design) } New optional Data Transfer Software, SEDACOM V2.0 parameters measured Specifications fraction of Turn Dimension of the container– cylinder Dimension of the container– Bowl units of 1/4 turns (selectable) 400 mm (15.8 in) diam, 300 mm (12 in) High 400 mm (15.8 in) diam, 200 mm (8 in) High } Number of partial and complete left and right turns (control unit) Ordering Information Order # 76-0244 76-0245 76-0555 76-0556 76-0247 76-0242 76-0243 76-0406 76-0608 RefeRences Iderberg H et al. (2015) Activity of serotonin 5-HT1A receptor ‘biased agonists’ in rat models of Parkinson’s disease and l-DOPA-induced dyskinesia. Neuropharmacology. 2015 Jun;93:52-67. Molinet-Dronda F et al. (2015) Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson’s disease: A longitudinal in-vivo study. Neurobiol Dis. 2015 May;77:165-72. } Data given by user-defined time intervals (multicounter and SEDACOM) components required Model Le902-Sr Le902-aS Le902-aSe Le902bt Le902-rP Le902-cc Le3806 Product Left & right rotation Sensor, adjustable turn resolution rat Harness with Soft ring and connecting wire mouse Harness with Soft ring and connecting wire bowl container with Supporting rod cylindrical container with Supporting rod Double counter (Left & right turns) Programmable multicounter with 30 inputs (up to 15 rotameters) } Rotation sensor and support } Animal harness } Container (either a bowl or a cylinder) } Cables and connectors } Instruction manual } 2 year warranty options Optional Accessories SeDacomV2.0 SeDacom V2.0 conrS232uSb rS232/uSb adapter } Double counter (left & right turn) } Programmable counter with 30 inputs (up to 15 Rotameters) 36 www.coulbourn.com • www.panlab.com