Learning Memory & Attention Passive Avoidance Box to Assess Working Memory Passive Avoidance is fear-motivated testing classically used to assess short-term or long-term memory on small laboratory animals. Passive Avoidance working protocols involve timing of transitions, i.e. time that the animal takes to move from the white compartment to the black one after a conditioning session. During the conditioning session, entry into the black compartment is punished with a mild inescapable electrical shock. Our Passive Avoidance box (LE870/872) is defined by a large white illuminated compartment and a small black dark compartment separated by a guillotine gate. The animal’s position is detected by using high sensitivity weight transducers providing accuracy and reliable detection (zones entries) systems utilizing photocell beams or on grid floor displacements. This Passive Avoidance Box is controlled by the ShutAvoid software. Learning Memory & Attention key features } Weight transducer technology for accurate animal detection } Very precise and stable intensity of shock delivered into the black compartment • Passive Avoidance Box to Assess Working Memory } Neither PC interface nor PC cards are required } Safety system which guarantees that the shock parameters measured intensity received by the animal is always the same value independent of the grid bars treaded Specifications Mouse Box Dimensions 250 x 250 x 240 mm (9.8 x 9.8 x 9.4 in) white compartment; (W x D x H) 195 x 108 x 120 mm (7.7x 4.3 x 4.7 in) black compartment Rat Box Dimensions (W x D x H) Min. Weight Detected Material composition Maximum number of stations connection of several Units to Pc certifications Power supply 310 x 310 x 240 mm (12 x 12 x 9.4 in) white compartment; 195 x 108 x 120 mm (7.7 x 4.3 x 4.7 in) black compartment 10 grams (mouse box); 40 grams (rat box) methacrylate, aluminum, stainless steel 8 stations connected to a Pc neither Pc interface nor Pc card are required. one cable connects all units to the Pc ce compliant 110/220 Vac, 50/60 Hz } Latency to enter into the black compartment components included } Passive Avoidance Box } Control unit with RS-232 communication port } Motorized door (controlled by the ShutAvoid software) } Cables and connectors } Instruction manual } 2 year warranty options } ShutAvoid software to control up to 8 Active or Passive boxes Ordering Information Order # Model 76-0199 76-0200 Options 76-0202 76-0159 SHutaVoiD Le10026 Software to control up to 8 active/Passive boxes Shock generator with, Scrambler, 0-2 ma output Le870 Le872 Product Passive avoidance cage, rats Passive avoidance cage, mice } LE10026 Shocker unit with scrambler (0-2mA output) RefeRences Orejana L et al. (2015) Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse. J Gerontol A Biol Sci Med Sci. 2015 Jun;70(6):675-85. (mouse) www.panlab.com • www.coulbourn.com 63