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Learning Memory & Attention
FreezeFrame Software for Fear Conditioning
Learning Memory & Attention
Ordering Information
Order # AcT-100A AcT-100A-U AcT-110 AcT-120 AcT-130 AcT-141 Product freezeframe Software (for 1-4 subjects) freezeframe upgrade to Version 3 freezeframe Shock control expansion Kit freezeframe Light/tone control expansion Kit freezeframe fan/House Light control Kit freezeframe audio expansion Kit
key features
} Only video-based system for fear conditioning,
a standard in the field
RefeRences Ainsley, J.A., Drane, L., Jacobs, J., Kittelberger, K.A., and Reijmers, L.G. (2014). Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience. Nature communications 5, 4510. Liu, C.C., Tsai, C.W., Deak, F., Rogers, J., Penuliar, M., Sung, Y.M., Maher, J.N., Fu, Y., Li, X., Xu, H., et al. (2014). Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer’s disease. Neuron 84, 63-77. Jahrling, J.B., Hernandez, C.M., Denner, L., and Dineley, K.T. (2014). PPARgamma recruitment to active ERK during memory consolidation is required for Alzheimer’s disease-related cognitive enhancement. The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 4054-4063. Heckman, L.D., Chahrour, M.H., and Zoghbi, H.Y. (2014). Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice. eLife 3:e02676 Chen, T., Lu, J.S., Song, Q., Liu, M.G., Koga, K., Descalzi, G., Li, Y.Q., and Zhuo, M. (2014). Pharmacological rescue of cortical synaptic and network potentiation in a mouse model for fragile X syndrome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 39, 1955-1967. Gomez, A.M., Froemke, R.C., and Burden, S.J. (2014). Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. eLife 3:e04287. Ramirez S, Liu X, Lin PA, Suh J, Pignatelli M, Redondo RL, Ryan TJ, Tonegawa S. (2013). Creating a false memory in the hippocampus. Science 341:387-91. Trouche S1, Sasaki JM, Tu T, Reijmers LG. (2013) Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses. Neuron. 80:1054-65. Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR, Lafaille JJ, Hempstead BL, Littman DR, Gan WB. (2013) Microglia promote learning-dependent synapse formation through brainderived neurotrophic factor. Cell. 155:1596-1609. A. S. Sengar, J. Ellegood, A. P. Yiu, H. Wang, W. Wang, S. C. Juneja, J. P. Lerch, S. A. Josselyn, R. M. Henkelman, M. W. Salter, and S. E. Egan (2103) Vertebrate Intersectin1 Is Repurposed to Facilitate Cortical Midline Connectivity and Higher Order Cognition The Journal of Neuroscience 33: 4055-4065. Qi Shi, Marguerite Prior, Xiangdong Zhou, Xiaoying Tang, Wanxia He, Xiangyou Hu, and Riqiang Yan (2013) Preventing Formation of Reticulon 3 Immunoreactive Dystrophic Neurites Improves Cognitive Function in Mice. The Journal of Neuroscience 33: 3059-3066. Carmelina Gemma, Matthew Fister, Charles Hudson, Paula C. Bickford (2013) Improvement of memory for context by inhibition of caspase-1 in aged rats. European Journal of Neuroscience22:1751–1756. Miho Terunuma, Raquel Revilla-Sanchez, Isabel M. Quadros, Qiudong Deng, Tarek Z. Deeb, Michael Lumb, Piotr Sicinski, Philip G. Haydon, Menelas N. Pangalos, and Stephen J. Moss (2013) Postsynaptic GABAB Receptor Activity Regulates Excitatory Neuronal Architecture and Spatial Memory The Journal of Neuroscience 34: 804-816. Liu, X., Ramirez, S., Pang, P.T., Puryear, C.B., Govindarajan, A., Deisseroth, K., and Tonegawa, S. (2012). Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature 484, 381-385. Lugo, J.N., Brewster, A.L., Spencer, C.M., and Anderson, A.E. (2012). Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. Learning and Memory 19:182189.
} Optimization of sensitivity with automation
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} Proprietary motion detection algorithm to filter out } Superior performance in low light
FreezeFrame Software for Fear Conditioning
shadows, light flicker and camera noise – detecting movements as small as 1 mm
FreezeFrame is the first video-based system for fear conditioning and has become the standard in its field. Combining the sensitivity of the human observer with the objectivity and throughput of automation, FreezeFrame is able to measure minute movements of grooming, sniffing, turning and rearing. The animal is monitored 2-4 times per second for data that is far more objective and reproducible. FreezeFrame can also be utilized for learned helplessness experiments, including tail suspension test and the Porsolt Forced Swim Test. FreezeFrame is not a tracking system – featuring a proprietary motion detection algorithm, the system filters out shadows, light flicker and camera noise to detect movements as small as 1 mm. FreezeFrame offers superior performance in low-light and is fully validated, with greater than 90% concordance with trained human observers. Easily store and recall multiple stimulus protocols for training and testing phases. Video images can be stored for future review and also exported as QuickTime and AVI movies for presentation. Batch export of data and analyses to Excel allows for easy analyzing of % freezing, number of bouts, bout duration and intervals for specified periods. Either white noise or pure tone can be delivered through the computer’s sound card. The FreezeFrame system accommodates multiple sounds of different amplitude, frequency and quality throughout a single trial. Stimuli – including lights, external sound generators and/or shock generators are also controlled though the computer.
note
Please contact your local sales and application specialist for more information on the environmental hardware and accessories available for the test cage configuration.
www.panlab.com
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www.coulbourn.com
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