Analgesia Paw & Tail Pressure Meter for Evaluating Mechanical Pain The conic point is mounted on an extensiometric load cell, making possible the visualization on the digital display of the current force applied at each moment of the test (grams). The motor and tip units are mounted on a pivoting stand preventing any excess pressure on the animal paw. The control unit makes possible the adjustment of the force transducer, balance and reset, as well as the selection of the step-motor current speed. A remote foot-switch controls the motor allowing rapid hands-free experiments. An automatic system is activated once the distal extreme of the sliding support track is reached or when the pedal is released at the test ending point. Then, the motor reverse its rotation at its higher speed, sliding up the conic tip again. SEDACOM software can be used to automatically record the results on a with our RS-232/USB adapter. Analgesia • Rat Paw Pressure Meter for Evaluating Mechanical Pain key features } Digital display } Pressure increasing rate adjustment } Footswitch control parameters measured Specifications Power supply stimuli Resolution Maximum stimuli Material composition certifications control Unit Dimensions (W x D x H) 110/220 Vac, 50/60 Hz 1 gram 999 gram methacrylate ce compliant 350 x 350 x 130 mm (14 x 14 x 5 in) } Pressure applied on the paw until the withdrawal or animal vocalizes (rats) } Pressure applied on the tail until withdrawn (mice) } Pressure applied on the paw until a flexor response of the toes (mice) components included } Control unit with RS-232 communication port to PC } Stimulation unit } Pedal switch } Flat and pointed tip points } Instruction manual } Cables and connectors } Set of spare fuses } 2 year warranty options stimulation Unit Dimensions (W x D x H) 150 x 210 x 166 mm (6 x 8.3 x 6.5 in) Ordering Information Order # 76-0234 Options 76-0406 76-0608 RefeRences Elhabazi K et al. (2014) Assessment of morphine-induced hyperalgesia and analgesic tolerance in mice using thermal and mechanical nociceptive modalities. J Vis Exp. 2014 Jul 29;(89):e51264 (tail pressure, mouse, France) Balakumar M et al. (2013) Benefits of early glycemic control by insulin on sensory neuropathy and cataract in diabetic rats. Indian J Exp Biol. 2013 Jan;51(1):56-64. (Paw pressure, rat) Spanevello MD et al. (2013) Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats. J Neurotrauma. 2013 Jun 15;30(12):1023-34. (Paw pressure, rat) Weibel R et al. (2013) Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: Insight from Conditional Knockout Mice. PLoS One. 2013 Sep 12;8(9):e74706. (Tail pressure, mouse) Sánchez Robles EM et al. (2012) Cannabinoids and muscular pain. Effectiveness of the local administration in rat. Eur J Pain. 2012 Sep;16(8):1116-27. (paw pressure, rat) Model Le7306 SeDacomV2.0 conrS232uSb Product rat Paw Pressure analgesia-meter SeDacom V2.0 rS232/uSb adapter } SEDACOM software } RS-232/USB Adapter The Randall & Selitto test is based on determination of the animal threshold response to pain induced in the paw by the application of a increasing pressure. In the LE7306 paw-pressure, a stimulation unit allows the gradual increase (at selectable rates) of the pressure applied on the animal paw. The pressure increase is achieved by a step-motor inducing the progressive advancement of a sliding support with a distal conic tip (1 mm diameter). 48 www.coulbourn.com • www.panlab.com