Analgesia Hot/Cold Plate for Testing Animal Sensitivity plate, reacting to the discomfort. The front panel timer then displays the number of seconds the animal took to react. Animal reaction time is a measurement of animal resistance to pain and is used to measure efficacy of analgesics. The plate is designed to be very simple to use and very fast to reach the set temperature (as example from ambient to 4°C, the most used threshold value, it takes less than 10 minutes, and from 4°C to 65°C it takes only 5 minutes). The Hot/Cold Plate, is accurate to less than 0.5°C (EEC metrology standard) and perfectly constant in the animal holder system. The preset temperature will not change for more than 0.1°C when a 400g rat is placed on the plate, and return to the set temperature is almost immediate. In addition, the instrument can be adjusted to be used for “TEMPERATURE RAMPS” Predefined by the user, this . feature is mainly used for studies with telemetry implants. In addition to displaying the reaction time, the Cold/Hot Plate Analgesia Meter is capable of sending data via USB interface to a computer. key features Analgesia • Hot/Cold Plate for Testing Animal Sensitivity } Unmatched temperature stability and control for both hot and cold The operator can start and stop the timer with the front panel start/stop switch or with the included footswitch, which allows “hands-free” operation. } Fast acclimation to set temperatures } Homogeneous temperature surface distribution } BSRamp software will allow the user to define temperature ramps (slope in °C/min, start and end points) and store results parameters measured Specifications Temperature Range Temperature Accuracy Temperature Uniformity Power Requirements Dimensions: Plate control Unit Weight 165 x 165 mm (6.5 x 6.5 in) 305 x 280 x 158 mm (12 x 11 x 6 in) 6.5 kg -3°c to 65°c (in 20°c to 25°c ambient environment, 50% rH) ±0.5°c ±0.5°c on Plate 110/220 Vac automatic, 100 w } Animal reaction time to hot or cold stimulus components included } Stimulation Unit } Footswitch } USB cable } BSRamp software } Instruction manual } One year warranty The Hot/Cold Plate Analgesia Meter is based on a metal plate which can be heated to 65°C and cooled to -3°C (with an ambient temperature between 20°C and 25°C). An electronic thermostat maintains the plate’s temperature and the front panel displays the temperature. The animal’s pain sensitivity resulting from exposure to heat or cold is tested by placing the animal on the surface of the plate and starting a built-in timer. The operator stops the timer at the instant the animal lifts its paw from the Ordering Information Order # 76-0112 RefeRences Celik F et al. (2014) Therapeutic effects of thymoquinone in a model of neuropathic pain. Curr Ther Res Clin Exp. 2014 Jan 2;76:11-6. (Neuropathy, rat, Turkey) Oliveira A et al. (2014) Morphine glucuronidation increases its analgesic effect in guinea pigs. Life Sci. 2014 Jul 30;109(2):104-10. (Guinea pig, Portugal) Piel MJ et al. (2014) Pain assessment in animal models of osteoarthritis. Gene. 2014 Mar 10;537(2):184-8. (review, USA) Model Le7420 Product Hot/cold Plate including bSramp Software 42 www.coulbourn.com • www.panlab.com