Analgesia Tail Flick Meter for Evaluating Thermal Analgesia with its tail protruding on the platform of the stimulus unit. The animal’s tail is positioned on a slot of adjustable width equipped with a groove that guarantees a correct placement. A remote foot-switch controls the test start/stop allowing rapid hands-free experiments. A photo beam with adjustable sensitivity detects the tail flick and the latency is automatically presented on a digital display on the control unit. Measurements of reaction time are given with a 0.1 precision. A cut-off time can be set to avoid tissue damage (by default: 20 s). The groove system for the tail and the adjustment of response sensitivity ensure optimum repeatability and reliability of results. SEDACOM software can be used to automatically record the results on a PC through a RS-232 port with our RS-232/ USB adapter. Analgesia • Tail Flick Meter for Evaluating Thermal Analgesia key features } Optimal detection due to perfect alignment of heat stimulus and photo beam trigger } Photo beams with adjustable sensitivity } A light beam shows the point on which the heat source will focus } Manual and remote timer and trigger } Groove for correct tail placement } Automatic cut-off } New optional data transfer software, SEDACOM V2.0 parameters measured } Time latency response to thermal stimulus components included } Control Unit with RS-232 port to PC } Stimulation unit } Mouse tail adapter } Holder for rat or mouse - must specify at time of order } Footswitch } Instruction manual } Calibration certificate } Cables and connectors } Set of spare fuses } 2 year warranty options } LE7106T Tail-Temperature recorder } SEDACOM software } RS-232/USB Adapter Specifications control Unit Dimensions (W x D x H) Power supply Material composition certifications 350 x 350 x 130 (14 x 14 x 5 in) 110/220 Vac, 50/60 Hz methacrylate, Halogen Lamp ce compliant stimulation Unit Dimensions (W x D x H) 400 x 140 x 155 (16 x 5.5 x 6 in) Ordering Information Order # 76-0293 76-0183 76-0184 76-0185 76-0186 76-0187 76-0188 Options 76-0406 76-0608 76-0294 RefeRences Park J et al. (2015) Pain perception in acute model mice of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Mol Pain. 2015 May 17;11:28. Bhalla S et al. (2015) Endothelin ETA Receptor Antagonist Reverses Naloxone-precipitated Opioid Withdrawal in Mice. Canadian Journal of Physiology and Pharmacology, 10.1139/ cjpp-2015-0022 Rodríguez-Gaztelumendi A et al. (2014) An altered spinal serotonergic system contributes to increased thermal nociception in an animal model of depression. Exp Brain Res. 2014 Jun;232(6):1793-803. Model Le7106 Le5016 Le5018 Le5020 Le5022 Le5024 Le5025 SeDacomV2.0 conrS232uSb Le7106t Product tail flick analgesia meter mice restrainer (small animals) mice restrainer (large animals) rat restrainer 150 gr. rat restrainer 250 gr. rat restrainer 400 gr. rat restrainer 500 gr. SeDacom V2.0 rS-232/uSb adapter tail-temperature recorder This system features radiant heat applied on the animal’s tail; when the animal feels discomfort, it reacts by a sudden tail movement (tail flick) which automatically stops the stimulation and the timer for the measurement of the animal reaction time (period from the beginning of the stimulation until detection of the animal’s response). This test has proved particularly sensitive for studying the analgesic properties of pharmacological substances. It can also be used to evaluate basal thermal pain sensitivity or to study putative genetic differences among control animals. The LE7106 Tail-flick Meter consists of a stimulation unit (containing the halogen lamp for the heat stimulus) and an electronic control unit. The system can be used for rats and mice of different sizes. The animal is placed in a restrainer 40 www.coulbourn.com • www.panlab.com