The Most Popular Mouse Isolated Lung Perfusion System

The IPL-1 is engineered specifically for the fragile mouse heart. The basic system can easily be upgraded to add capability modules for virtually any ex vivo pulmonary assay.

Due to the fragile nature of the mouse lung, its suspension from the tracheal and vascular cannulae is difficult to accomplish without the rapid occurrence of edema. In collaboration with experts in pulmonary physiology, a design was developed which allows for ventilation and perfusion with the lungs remaining in situ at a slight incline in the open thorax.. This novel approach simplifies cannulation of the pulmonary artery and left atrium of the heart and dramatically reduces edema formation.

The isolated mouse lung can be ventilated under positive pressure and under subatmospheric pressure to mimic the in vivo situation as closely as possible. There are bigger differences in vascular flows seen between positive and negative ventilation. Depending on the study, a ventilated lung or a physiologic breathing lung can be simulated.

To ensure that your system is properly configured as a functional unit that meets your application needs, please complete our Checklist and then contact Technical Services at 800-547-6766 or or via email at  support@hbiosci.com before placing an order. In Europe, please call +49 7665 92000 or email at  sales@hugo-sachs.de.

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Isolated Perfused Lung Systems for Mouse (IPL-1)

IPL-1 Core Isolated Perfused Lung System for Mouse The IPL-1 is an ex vivo lung perfusion system (EVLP) specifically engineered for the fragile --> Learn More
Ventilation Options for IPL-1 For a functional IPL-2 unit the core system requires a suitable ventilation system.For only --> Learn More
Perfusate Deoxygenation Option for IPL-1, IPL-2 and IPL-4 Add this option to IPL-1, IPL-2 and IPL-4 to deoxygenate blood or buffers containing proteins --> Learn More
pH Control Unit for IPL-1 and IPL-2 This option controls and regulates the pH in the buffer solution by carefully bubbling it --> Learn More
Perfusion Solution Electrochemical Monitoring for All Isolated Organ Systems This option permits precise continuous monitoring and measurement of three key parameters, --> Learn More
Venous Pressure Measurement Option for all IPL Systems This option provides a venous pressure transducer and amplifier for venous pressure --> Learn More
Drug Addition Options for All Isolated Organ Systems These options for drug addition can be added to any isolated organ system where flow is --> Learn More
Temperature Measurement Option for All Isolated Organ Systems Perfusate temperature can be measured in one of two ways:with the PLUGSYS Thermocouple --> Learn More
Perfusate Filtration Option for All Isolated Organ Systems This option enables filtration of recirculated perfusate in any isolated organ system. --> Learn More

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