The Isolated Perfused Lung (IPL) method is invaluable for characterizing the non-respiratory capabilities of pulmonary tissues such as pulmonary metabolic activity as well as the activities of various components (pulmonary alveolar macrophage, alveolar tissue, endothelial tissue, etc) in response to inhaled/airborne particulates/therapies. Isolated lung systems are equally useful for evaluating respiratory functions such as respiratory mechanics and gas exchange. The lungs, while being removed from the body, are still an intact functional organ, unlike other in vitro methods such as slices and cultures, and therefore can continue in their physiological function without the interference from the CNS and other systems of the living organism.

The HSE system architecture utilizes a unique technology to enable seamless switching between positive and negative pressure ventilation on all models from Mouse to Rabbit/Fetal Pig. Negative pressure ventilation is the natural method of breathing for the lung and has been demonstrated to allow a much increased pulmonary artery flow and decreased edema formation in comparison to positive pressure ventilation. Combined with constant pressure perfusion, optimal physiologic lung function can be more easily achieved.

Systems begin at basic perfusion and ventilation and can become complete Respiratory Mechanics Workstations with a range of measurement devices, signal conditioning equipment, and acquisition & analysis software, providing a superior solution for virtually any study.

All functional isolated organ systems require the following components:

Building your system is as simple as selecting the basic system for your lung model and then adding various options to suit the particular needs of your study. Please email Technical Services for assistance with your system configuration or application support or call us at 800-547-6766.