PULMODYN Data Acquisition Software for Respiratory Experiments
Ponemah PULMODYN Software: Ponemah Software has been trusted by researchers worldwide for over 3 decades to discover new insights into their research applications. Ponemah PULMODYN software is tailored to acquire, visualize, and report physiologic endpoints. A wide range of essential respiratory and hemodynamic metrics can be derived in real time from the primary signals acquired from in vivo models or ex vivo lung perfusion setups.
- Data acquisition, visualization, and analysis of in vivo or ex vivo respiratory and hemodynamic signals.
- Accurate and consistent results through industry validated algorithms.
- Adjust algorithm settings to optimize signal analysis from various species and unique morphologies.
- Acquisition of primary signals from our DSI* ACQ-7700 signal conditioners or HSE* PLUGSYS Modules as well as third-party analog signals.
- Built-in visualization tools to explore data and gain complete confidence in your results.
- Fast-tracks subsequent experiments by saving settings as a reusable Protocol.
- Immediate results with real-time data visualization and analysis with visual validation marks.
- Refine results by re-analyzing data segments post-hoc and/or changing mark placement.
*Data Sciences International (DSI), Hugo Sachs Elektronik (HSE) and Harvard Apparatus are all divisions of Harvard Bioscience, Inc. (HBIO)
To ensure that your system is properly configured as a complete setup that meets your experimental needs, please email us at sales@harvardapparatus.com or call us at 800-597-0580. In Europe, please call +49 7665 92000 or email sales@hugo-sachs.de.
Additional Resources:
- Complete line of HSE/HA Isolated Lung Perfusion Systems
- Tissue Bath Systems for Tracheal Ring Studies
- HSE PLUGSYS Cases and Modules
- HSE Data Acquisition Hardware
- DSI ACQ-7700 Cases and Signal Conditioners
- Other Ponemah Platforms including CARDIO, TISSUEPRO and BDAS
Ponemah PULMODYN is a comprehensive data acquisition and analysis platform for all your respiratory study needs. Primary respiratory airflow and airway, thoracic or esophageal pressure and hemodynamic signals are acquired using one of several available data acquisition hardware setups. PULMODYN derives secondary signals (e.g. tidal volume) in real time from the primary signals. Data visualization, analysis and reporting features, saved acquisition and analysis protocols allow you to rapidly go from data collection to visualization and analysis.
Data Analysis Modules Included with Ponemah PULMODYN*
Each data analysis module derives a wide range of scientifically validated, industry approved pulmonary endpoints.
- Pulmonary Compliance & Resistance (PCR/PCRP)
- Pulmonary Air Flow and Airway Resistance (PAF) Included with PCR
- Systemic Blood Flow (SBF)
- Blood Pressure (BP)
*Expand the specifications section below for a complete list of parameters derived from the primary signals
Reliable Data Services: We also offer Data Analysis as a service. We can assist with the creation of high quality, usable reports that summarize your experimental data and freeing up your time to evaluate the experimental results and plan your future studies.
- DSI Scientific Services for assistance in study setup and data analysis.
- Customized report packages for summarizing experimental data.
- Saves time, enhances confidence in results, and facilitates planning for future experiments.
Pulmonary Air Flow and Airway Resistance (PAF)
Analyzes any derived pulmonary signal derived and draws automated validation marks for Start of Inspiration, Start of Expiration and Start of Apnea and other parameters.
The list below describes the parameters calculated either in real-time or during subsequent analysis.
| Name | Definition |
|---|---|
| Num | The number of the respiratory cycle. |
| PIF | Peak Inspiratory Flow is the maximum inspiratory flow that occurs during a valid breath. |
| PEF | Peak Expiratory Flow is the maximum expiratory flow that occurs during a valid breath. |
| TV | The Tidal Volume is the total volume of air that was inspired during a breath and is always reported in millimeters. |
| MV | The Minute Volume is the product of the tidal volume and the number of breaths-per-minute. |
| BPM | The number of breaths-per-minute is calculated on a breath-to-breath basis. |
| IT | The Inspiratory Time is calculated from the first zero crossing of the flow in the inspiratory direction to the zero crossing of the flow in the expiratory direction. The time is in milliseconds. |
| ET | The Expiratory Time is calculated from the zero crossing of the flow in the expiratory direction until flow reaches zero again. The time is in milliseconds. |
| TT | The Total Time is the time period, in milliseconds, from one valid breath to the next valid breath. |
| AT | The Apnea Time. |
| CaRaw (only AWR) | Specific Airway Resistance . This parameter is the product of Alveolar Compliance and Airway Resistance |
| Phase | Phase shift between mouth and chest volume, in degrees. For JET RIP, this represents the phase difference between the chest and abdomen. |
| dT(only AWR) | The delay , in milliseconds, between the mouth and chest volumes. |
| PEnh | Enhanced Pause. |
| RT | Relaxation Time. This is the time from the start of expiration to the point where the volume signal drops by the Percent Relaxation value from its maximum value for the cycle. |
| TVe | This is the difference between the volume at the start expiration mark and the volume at the point prior to the next cycles start inspiration mark. It is always reported in milliliters. |
| IF50 | IF50 reports the inspiratory flow value at the point where the volume signal rises to 50% of the tidal volume. |
| EF50 | EF50 reports the expiratory flow value at the point where the volume signal drops to 50% of the tidal volume. |
| AVol | Accumulated Volume is the summed total of the Tidal Volume (TV) from a reset point forward and is reported in milliliters. |
Pulmonary Compliance & Resistance (PCR/PCRP)
Analyzes pulmonary signals from a pneumotachometer, along with a pressure, in isolated organ models or in vivo anesthetized animals. Values for these derived signals are calculated on a breath-to-breath basis for each respiratory cycle.
The list below describes the parameters calculated either in real-time or during subsequent analysis.
| Name | Definition |
|---|---|
| Num | The number of the respiratory cycle. |
| PIF, PEF | Peak Inspiratory Flow, Peak Expiratory Flow. |
| TV, MV | Tidal Volume, Minute Volume |
| BPM | The number of breaths-per-minute is calculated on a breath-to-breath basis. |
| IT, ET, TT, AT | Inspiratory Time, Expiratory Time, Total Time, Apnea Time. |
| Cdyn, Res, Cond | Compliance, Resistance, Conductance. |
| ResI1, ResI2, ResE1, ResE2 | Resistance calculated at various points of inspiration and expiration. |
| CAvg, RAvg | Compliance and Resistance value averaged. |
| PInspS(P1), PExpS(P2), Piso1(P3), Piso2(P4) | Pressure value at different time points of flow signal. |
| Fiso1(F1), Fiso2(F2) | Flow on clearing isovolumic levels during inspiration and expiration. |
| PEnh | Enhanced Pause. Calculated as: ((ET+AT)/RT-1)*(PEF/PIF). Formula from Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysomgraphy Hamelmann et al. |
| RT | Relaxation Time. |
| WOBi, WOBe, WOB | Work of Breathing Inspiration, Work of Breathing Expiration and Work of Breathing (sum) |
| POBi, POBe, POB | Power of Breathing Inspiration, Power of Breathing Expiration and Power of Breathing (rate at which work was performed over inspiration and expiration). |
| TVe | The difference between the volume at the start of expiration mark and the volume at the point prior to the next cycles start inspiration mark. |
| AVol | Accumulated volume. |
| IF50 | Inspiratory flow value at the point where the volume signal rises to 50% of the tidal volume. |
| EF50 | Expiratory flow value at the point where the volume signal drops to 50% of the tidal volume. |
Systemic Blood Flow (SBF) Analysis
Analyzes systemic blood flow from the circulatory system and eliminates drift resulting from certain types of flow meters.
The list below describes the parameters calculated either in real-time or during subsequent analysis.
| Name | Definition |
|---|---|
| Num | The number of the cardiac cycle. |
| Mean | The integrated level of the flow for the cardiac cycle. |
| FMax | Maximum Flow that occurred for a cardiac cycle. |
| FMin | Minimum Flow that occurred for a cardiac cycle. |
| CO | Cardiac Output is the mean flow normalized to ml/Min. Note: When running in a logging mode other than 1 epoch, the CO value will be calculated from the averaged mean flow value. |
| SV | Stroke Volume. |
| +dQ | +dQ is the maximum positive value of the first derivative of the flow that occurs during the cardiac cycle. |
| Iso | The value of flow during the rapid up rise of the flow signal. |
| TPR | Total Peripheral Resistance. |
| NPMN | The non-pulsatile mean calculated over the complete logging interval. |
Blood Pressure (BP) Analysis
Analyzes arterial and venous pressures. Pulse Wave Velocity calculations are also available when combined with two arterial pressure transducers and compatible amplifiers.
In addition to displaying aortic pressure recordings, validation marks are automatically set for Diastolic, End Diastolic, Systolic. In addition, users can define and display % Recovery Point.
The list below describes the parameters calculated either in real-time or during subsequent analysis.
| Name | Definition |
|---|---|
| Num | The number of the cardiac cycle. |
| Sys, Dia, Mean | Systolic, Diastolic, and Mean pressure. |
| PH, HR, TTPK, ET | Common parameters include Pulse height, Heart rate, Time to peak, Ejection time. |
| +dP/dt, -dP/dt | Maximum positive and negative value of the first derivative of the pressure. |
| %REC | The amount of time it takes the pressure to recover. |
| NPMN | Non-pulsatile mean pressure. |
| Q-A | The Q-A Interval is the time in milliseconds from the start of the Q-wave, in the ECG trigger channel, to the start of the systolic pressure rise. |
| Mean2 | An alternate representation for Mean calculated as (Systolic + 2 * Diastolic)/3. |
| PTT | Pulse Transit Time (PTT) is the time between the prior systolic time of the upstream channel and the systolic time of the selected channel. This time is reported in ms. |
| PWV | Pulse Wave Velocity (PWV) is the velocity calculated by using the Pulse Wave Distance (PWD) and Pulse Transit Time (PTT). PWV is calculated as: Pulse Wave Velocity = Pulse Wave Distance / Pulse Transit Time. |
| IBIs, IBIms, IBIed | Inter-Beat Interval (IBI) is the time in milliseconds between cardiac cycles and allows Heart Rate Variable (HRV) to be calculated from Blood Pressure signals (Frequency Domain). |
| Count | Reports the number of cycles in a given logging period. |
