Working Heart Upgrade for IH-SR Core System

Working Heart Upgrade for IH-SR Core System

Upgrade an IH-SR Langendorff configuration to an IH-SR Working Heart (according to Neely) System.

  • Fully-ejecting working heart model for physiological cardiovascular studies in small rodents.
  • Allows rapid and easy switching between Working Heart (Ejecting Heart) and Langendorff modes.

To ensure that your system is properly configured as a functional unit that meets your application needs, please complete our Checklist and then contact Technical Services at 800-547-6766 or via email at support@hbiosci.com before placing an order. In Europe, please call +49 7665 92000 or via email at sales@hugo-sachs.de. Upgrades can also be modified to meet your specific needs.

Item# Description U.S. List Price Quantity
73-4347 Working Heart Option to IH-SR Basic System, 230 VAC
73-4349 Working Heart Option to IH-SR Basic System, 115 VAC
73-4033 Additions to Working Heart Option for Mouse Hearts
73-4034 Additions to Working Heart System for Rat Hearts
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Upgrade an IH-SR Lagendorff Core System to a IH-SR Working Heart (according to Neely) System by adding a Working Heart option and one of the species-specific additions.

This upgrade provides a fully-ejecting working heart model for physiological cardiovascular studies, e.g. cardiac function and metabolism, while allowing rapid and easy switching between Working Heart (Ejecting Heart) and Langendorff modes.

Researchers who know they will be upgrading to working ejecting heart in the future typically start with a Langendorff Working Heart-Ready configuration. However, a Langendorff Only configuration can easily be modified to a Langendorff Working Heart-Ready configuration. Please contact our technical team for help!

Features & Benefits
Applications
Measured Signals
Options
Species-Specific Additions


Features & Benefits

  • Optimized atrial cannulating conditions—true aortic flow and pressure signals (no bouncing afterload)
  • Short atrial fill time (low flow resistance)—optimal ventricle filling
  • Low resistance and dead space volume
  • Minimal temperature and oxygen loss
  • Unique vascular afterload system using a membrane—optimal vascular system including compliance simulation
  • Physiological atrial and arterial pressure waveform—avoids non-physiological pressure wave; no dynamic pressure effects or altered coronary flow
  • Read constant preload system—preload pressure independent of the atrial flow; no stress on mitral valve
  • Low aortic cannula flow resistance—possible to insert a Millar transducer for LVP or LVP/Volume measurement
  • No liquid pressure column as afterload—less stress on valves
  • All electrodes, catheters and probes are fully enclosed  in the unique closed jacketed chamber—easy, direct access to the heart and to maintain physiological conditions while performing the experiments.


Applications


Measured Signals

All parameters of standard Langendorff plus the following signals can be recorded:

  • Preload (left atrial preload / ventricular filling pressure)
  • Afterload (determining the diastolic and systolic aortic pressure)
  • Left ventricular pressure or pressure-volume loops
  • Atrial, aortic and coronary flow


Options

   IHSR-WH, Working Heart Upgrade, 230 V (73-4347) includes:   IHRS-WH Working Heart Upgrade, 115 V (73-4349) includes:
73-2818 Working Heart Option to IH-SR Core System 73-2818 Working Heart Option to IH-SR Core System
72-6432 Ecoline VC-MS/CA8-6, 230 VAC 72-6433 Ecoline VC-MS/CA8-6, 115 VAC
73-0155 AME 24 - SC0072 Pump Tubing (Tygon) 3-stop collared (Pack of 12)
73-0155 AME 24 - SC0072 Pump Tubing (Tygon) 3-stop collared (Pack of 12)
73-1839 AME 25 - SC0224 Pump Tubing (Tygon) 3-stop collared (Pack of 12) 73-1839 AME 25 - SC0224 Pump Tubing (Tygon) 3-stop collared (Pack of 12)
73-0020 Blood Pressure Transducer P75 for PLUGSYS Module 73-0020 Blood Pressure Transducer P75 for PLUGSYS Module
73-0065 PLUGSYS Transducer Amplifier Module (TAM-A) 73-0065 PLUGSYS Transducer Amplifier Module (TAM-A)
73-3440 Jacketed Reservoir for Buffer Solution with Frit, 2 L 73-3440 Jacketed Reservoir for Buffer Solution with Frit, 2 L
73-3456 Tube Set for Jacketed Buller Reservoir with Fluid Line Shutoff Valves 73-3456 Tube Set for Jacketed Buller Reservoir with Fluid Line Shutoff Valves

 

Species-Specific Additions

 

  IHSR-WH-M for mouse (73-4033)   IHSR-WH-RGP for rat / guinea pig (73-4034)
73-2817 Atrial Cannula for Mouse Heart, 1.3 mm OD 73-2815 Atrial Cannula for Rat Heart, 2.3 mm OD



Specifications