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Cardiovascular Waveform Pump

Price on Request
SKU
8481d828

The Cardiovascular Waveform Pump (former name Pulsatile Blood Pump) simulates the ventricular hemodynamic waveform of the heart. It features silicone rubber-covered heart-type ball valves and smooth flow. Only inert materials like silicone rubber, acrylate, and PTFE contact the fluid. The pumping head is easy to take apart and reassemble and can be sterilized. It can be used for circulating emulsions, suspensions, and non-Newtonian fluids such as blood. Actuation of the ball check valves will result in some hemolysis over time when using blood or blood cell doped solutions but acute use with these solutions in mock circulatory loops can be performed. Four different models are available with minute volumes of 1 - 200 ml, 10 ml – 2 L, 80 ml – 6 L, 150 ml – 10 L. It is ideal for testing flow circuits and medical devices that require ventricular hemodynamic flow morphology.

Tubing listed in the table below for connection to inlet and outlet pump ports. Other tubing formulations and sizes as well as connector kits are available.

We offer turnkey solutions to measure pressure and flow throughout your perfusion circuit. Please contact us for assistance configuring a setup that meets your experimental needs: email us at sales@harvardapparatus.com or call us at 800-597-0580. In Europe, please call +49 7665 92000 or email sales@hugo-sachs.de.

Grouped product items
Item No. Description Qty
52-9552 Cardiovascular Waveform Pump Model 1407 Please login to add to Quote
55-1838 Cardiovascular Waveform Pump Model 1405 Please login to add to Quote
72-1027 Tygon® E-3603 Tubing, 15.2 m (50 ft) Length, 7.9 mm (5/16 in) ID, 11.1 mm (7/16 in) OD; for Models 1405 & 1407 Please login to add to Quote
55-3321 Cardiovascular Waveform Pump Model 1421 Please login to add to Quote
72-1032 Tygon® E-3603 Tubing, 15.2 m (50 ft) Length, 11.1 mm (7/16 in) ID, 17.5 mm (11/16 in) OD; for Model 1421 Please login to add to Quote
55-3305 Cardiovascular Waveform Pump Model 1423 Please login to add to Quote
72-1033 Tygon® E-3603 Tubing, 15.2 m (50 ft) Length, 12.7 mm (1/2 in) ID, 17.5 mm (11/16 in) OD; for Model 1423 Please login to add to Quote

The Cardiovascular Waveform Pump (former name Pulsatile Blood Pump) simulates the ventricular hemodynamic waveform of the heart. It features silicone rubber-covered heart-type ball valves and smooth flow. Only inert materials like silicone rubber, acrylate, and PTFE contact the fluid. The pumping head is easy to take apart and reassemble and can be sterilized. It can be used for circulating emulsions, suspensions, and non-Newtonian fluids such as blood. Actuation of the ball check valves will result in some hemolysis over time when using blood or blood cell doped solutions but acute use with these solutions in mock circulatory loops can be performed. Four different models are available with minute volumes of 1 - 200 ml, 10 ml – 2 L, 80 ml – 6 L, 150 ml – 10 L. It is ideal for testing flow circuits and medical devices that require ventricular hemodynamic flow morphology.

 


Features

  • Reproduction of the ventricular hemodynamic waveform including temporal phasing of systole (dispensing) and diastole (refilling).
  • Durable construction for hours of continuous operation.
  • 4 flow rate range models, Minute volumes:
    • 1 - 200 ml, 10 ml – 2 L, 80 ml – 6 L, 150 ml – 10 L
    • Variable phasing for Models 1421 and 1423 (see specifications table)
  • Suitable for acute studies with bloodA, ideal for simulated blood solutions, other non-Newtonian solutions as well as aqueous solutions.

A. When using blood or blood cell doped solutions hemolysis will occur over time and is affected by the mechanical closing of valves, stroke rate and potentially the fluid pathway. The user is advised to determine change in hematocrit and/or free hemoglobin at various time points during the pumping of these solutions.

 


Pump Mechanism

A positive piston actuator and ball check valves provide the proportioning action. The product of stroke rate times stroke volume is an accurate indicator of the flow rate. Positive piston action prevents changes in flow rates, regardless of variations in resistance or back pressure. The piston always travels to the end of the ejection stroke, independent of the volume pumped.

We offer turnkey solutions including tubing, connectors, pressure transducers, flowmeters and data acquisition platforms to complete your experimental setup.

 


Test Setup with Pressure and Flow Values

A simple setup is presented in the figure below with a small compliance device (Penrose tubing).

 

 


Pressure Curves

The shape of the output pressure curve is a function of both the pump action and the characteristics of the external system on the output fluid circuit. The following set of curves were obtained with Model 1421, using water as the pumped medium. In the tests, pressure transducers were inserted in three locations and continuous records obtained under varying conditions.

Varying the peripheral resistance, stroke rate, stroke volume and phase ratio allows for creation of a wide range of output flow and pressure characteristics.

  • Curve A Pressure just beyond the output valve
  • Curve B Pressure within the pump chamber
  • Curve C Pressure just before the intake valve

 

 

Ex Vivo Organ Perfusion

An example of ex vivo organ perfusion pressure and flow values obtained from a dog lung lobe perfusion.

 

Item # 52-9552  55-1838  55-3321 55-3305 
Model No. 1407 1405 1421 1423
Stroke Volume Adjustable 0.05 to 1.0 ml 0.5 to 10 ml 4 to 30 ml 15 to 100 ml
Rate Stroke/Minute 20 to 200 20 to 200 20 to 200 10 to 100
Minute Volume Stroke Volume x Rate 1 to 200 ml 10 to 2,000 ml 80 to 6,000 ml 150 to 10,000 ml
Phasing* Fixed Phase Fixed Phase Adjustable Phase Adjustable Phase
  35% systole 35% systole 35 to 50% systole 35 to 50% systole
  65% diastole 65% diastole 65 to 50% diastole 65 to 50% diastole
Port ID 0.25” (6.35mm) 0.25” (6.35mm) 0.375” (9.52mm) 0.5” (12.7mm)
Port OD 0.325” (8.26mm) 0.325” (8.26mm) 0.44” (11.18 mm) 0.56” (14.22mm)
Tube ID 8 mm (0.31 in) 8 mm (0.31 in) 11 mm (0.437 in) 14 mm (0.551 in)
Dimensions H x W x D 312 x 156 x 250 mm
(12.3 x 6.1 x 9.9 in)
312 x 156 x 250 mm
(12.3 x 6.1 x 9.9 in)
500 x 212 x 337 mm
(19.7 x 8.4 x 13.4 in)
500 x 212 x 337 mm
(19.7 x 8.4 x 13.4 in)
Weight 7.3 kg (16 lb) 7.3 kg (16 lb) 13.6 kg (30 lb) 14.5 kg (32 lb)
Voltage 115 VAC, 50/60 Hz or 230 VAC, 50/60 Hz
UK and EU Models
115 VAC, 50/60 Hz or 230 VAC, 50/60 Hz
UK and EU Models
115 VAC, 50/60 Hz or 230 VAC, 50/60 Hz
UK and EU Models
115 VAC, 50/60 Hz or 230 VAC, 50/60 Hz
UK and EU Models

* Phasing = percentage of one cycle dispensing (systole) or refilling (diastole) pump piston

Hanna Schweighöfer1 , Christoph Rummel2 , Konstantin Mayer3 and Bernhard Rosengarten1* (2014 ) Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock Intensive Care Med Exp

Anna Skoczyńska,1 Anna Wojakowska,1 Dorian Nowacki,2 Łukasz Bobak,3 Barbara Turczyn,1 Beata Smyk,1 Andrzej Szuba,1 and Tadeusz Trziszka3 (2015 ) Unsaturated Fatty Acids Supplementation Reduces Blood Lead Level in Rats Biomed Res Int

Jörg W. Wegener*,1, Florian Loga*, David Stegner†, Bernhard Nieswandt† and Franz Hofmann* (2014 ) Phospholipase D1 is involved in α1-adrenergic contraction of murine vascular smooth muscle FASEB J