IPL-1 Core Isolated Perfused Lung System for Mouse

Price on Request

The IPL-1 is an ex vivo lung perfusion system (EVLP) specifically engineered for the fragile mouse lung. The core system can easily be initially configured with various system options of upgraded later are your needs change. 

The core system contains all the primary equipment to accomplish basic perfusion and ventilation experiments, requiring only the addition of core options for ventilation. Application-specific upgrades and options are also available.

Due to the fragile nature of the mouse lung, its suspension from the tracheal and vascular cannulae is difficult to accomplish without the rapid occurrence of edema. In collaboration with experts in pulmonary physiology, a design was developed which allows for ventilation and perfusion with the lungs remaining in situ at a slight incline in the open thorax. This novel approach simplifies cannulation of the pulmonary artery and left atrium of the heart and dramatically reduces edema formation.

The isolated mouse lung can be ventilated under positive pressure and under subatmospheric pressure to mimic the in vivo situation as closely as possible. There are bigger differences in vascular flows seen between positive and negative ventilation. Depending on the study, a ventilated lung or a physiologic breathing lung can be simulated.

Please note: For a functional unit, the core system requires the addition of core system options for ventilation. 

To ensure that your system is properly configured as a complete setup that meets your experimental needs, please email us at sales@harvardapparatus.com or call us at 800-597-0580.  In Europe, please call +49 7665 92000 or email sales@hugo-sachs.de.

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