Flow Measurement Options for UP-100IH, IH-SR and IH-5 in Langendorff and Working Heart Modes

Flow measurement can be accomplished in a functional IH system using two methods:

• Indirect measurement by controlling the pump speed of a roller pump (SCP controller)
• Direct measurement with Ultrasound Transit Time Technic (TTFM-2 module)

Applications

• Accurate coronary flow measurement on drug studies
• Studies on coronary resistance changes (pre and post ischemia)
• Myogene autoregulation (reactive hyperemia)

---

Constant Pressure/Flow Control

If you do "Langendorff only", the PLUGSYS Servo Controller Module (SCP) is used in combination with a roller pump to perfuse the heart in constant pressure mode. The SCP module calculates the coronary flow from the pump speed of the roller pump (indirect flow measurement). The PLUGSYS TAM-D module amplifies the measured perfusion pressure signal and outputs it to the data acquisition system. Both the roller pump and the TAM-D are included in the IH-SR and IH-5 Core Systems.

• Allows perfusion under constant pressure or constant flow (direct switchable)
• Provides accurate control of perfusion pressure or flow, even at very low flow rates
• Indirect coronary flow measurement from pump speed

---

Direct Flow Measurement with Ultrasound Transit Time Flowmeter

The PLUGSYS TTFM-2 module, in combination with a Starling Pressure Controller, provides real and accurate transit time flow measurement in ml/min for direct coronary flow measurement in retrograde Langendorff mode or aortic flow measurement in working ejecting heart. In addition, species-specific flow probes and adapters are required.

Features & Benefits

• Accurate ultrasonic transit time direct flow measurement
• Unique integration of flow probe into perfusion path
• Laminar flow lines improve accuracy of flow measurement
• Thermal properties of Perspex adapter reduce temperature loss
• Increased system flexibility by allowing the study of Myogene Autoregulation (Reactive Hyperemia)
• Indirect flow measurement can typically follow increasing flow rates but often lags behind decreasing flow rates

The table below specifies the flow probe and adapter to be used for each type of isolated heart system (IH-SR, IH-5 or UP-100IH) for the indicated application. It is extremely important to order the correct probe and adapter pair. If ordering online, please select carefully from the item listing or contact technical support for assistance.