IH-SR Core System Options

Additions to the IH-SR Core System for species-specific Langendorff Only or Langendorff Working Heart-Ready functional units

An IH-SR Langendorff functional unit requires the addition of core options to the selected core system (either 73-4343 or 73-4344). Specifically, the core system requires the addition of:

• Perfusion pressure controllers (SCP or Starling Resistor) 
• Species-specific addition (includes cannulae and balloons)

The core option and species-specific addition selected depend on:

• If you want a Langendorff Only configuration or a Working Heart-Ready Langendorff configuration. 
  • The Langendorff Only configuration can easily be modified to a Langendorff Working Heart-Ready configuration in the future.
  • Researchers who know they will be upgrading to working ejecting heart in the future often start with the Langendorff Working Heart-Ready configuration. 
• The species to be studied, i.e., mouse, rat or guinea pig

Core System Options

*Coronary flow measurement in this case is only possible by using an TTFM-2 flowmeter with flow probe.

Perfusion Pressure Controllers

PLUGSYS Servo Controller for Perfusion (SCP) Module (73-2806)

The SCP constant pressure/flow controller maintains perfusion either at constant pressure or at constant flow using a peristaltic pump. It provides accurate control of perfusion flow rate or pressure, even at very low flow rates. The SCP controller modulates the flow generated by the perfusion pump based on a perfusion pressure feedback loop. The controller also provides an accurate, low-cost way to indirectly measure coronary flow. The SCP calculates flow rate from pump speed, eliminating the need for an expensive flowmeter. It is required for Langendorff Only configurations.

• Allows operation in constant pressure or constant flow with simple switch
• Provides accurate control of perfusion pressure or flow, even at very low flow rates
• Flexible perfusion circuit setup adjustes to suit individual perfusion conditions

Additional measured signals/calculated parameters:

• Indirect coronary flow measurement
• Calculation of coronary resistance

Additional items required:

• PC-based data acquisition system

Starling Resistor for Perfusion Pressure Controller  (73-4346)

The perfusion pressure controller with Starling resistor provides constant pressure perfusion of the heart in Langendorff mode and acts as an afterload system in the working heart mode. It uses a Teflon membrane flow resistor, manometer and pressure syringe to create a pressure-controlled valve in the aortic block. It is required for a Langendorff Working Heart-Ready configuration. If coronary flow measurement is required, the use of the PLUGSYS ultrasonic transit time flow measurement module (TTFM-2) and flow probe will be required, as the SCP controller cannot make that measurement.

• Uses Teflon membrane flow resistor, manometer and pressure syringe to create a pressure-controlled valve in the aortic block.
• Mechanical device that does not provide flow information and does not alter the pump flow rate.
  • Flow rate is set high on the pump and only the flow that generates the set perfusion pressure is delivered to the heart while the remainder exits via the valve and returns to the reservoir.
• Must choose direct coronary flow measurement to capture coronary flow data.

Additional measured signal/calculated parameters:

• Coronary flow data (add Flow Measurement Optioin)

 Includes:

• Aortic block base unit with flange-mounted adjustable flow resistance
• Pressure syringe with mounting bracket
• Manometer

Species Specific Options