Oocyte Clamp (OC-725C)

Oocyte Clamp (OC-725C)

The OC-725C Oocyte Clamp is designed for two-electrode, whole-cell voltage clamping of Xenopus oocytes.

  • High compliance voltage (±180 V)
  • Unique bath clamp circuitry
  • Ideal for clamping large cells and cell structures e.g. squid axons
  • Extended current measuring range
  • Decreased noise level and 4-pole Bessel filter
  • An internal switch permits measurements of the current in series with the current electrode instead of in the bath
  • Optional differential voltage headstages
  • Voltage and current electrode holders must be purchased separately

Item# Description U.S. List Price Quantity
64-0028 OC-725C Oocyte Clamp Supplied with 7250V voltage headstage, 7251I bath clamp headstage, 7259C current cable, model membrane and rack mount hardware. Specify line operating voltage if other than 100-130 VAC. One straight holder and one 45° holder nee
64-1007 E Series Straight Body Electrode Holder; Wire w/ 2 mm Jack and Vent (for use with Warner Oocyte Clamp OC-725), 1.0 mm Glass ID
64-1008 E Series Straight Body Electrode Holder; Wire w/ 2 mm Jack and Vent (for use with Warner Oocyte Clamp OC-725), 1.2 mm Glass ID
64-1009 E Series Straight Body Electrode Holder; Wire w/ 2 mm Jack and Vent (for use with Warner Oocyte Clamp OC-725), 1.5 mm Glass ID
64-1010 E Series Straight Body Electrode Holder; Wire w/ 2 mm Jack and Vent (for use with Warner Oocyte Clamp OC-725), 2.0 mm Glass ID
64-1051 E Series with Handle; Wire with 2 mm Jack and Vent (for use with Warner Oocyte Clamp OC-725), 1.0 mm Glass OD
64-1052 E Series with Handle; Wire with 2 mm Jack and Vent (for use with Warner Oocyte Clamp OC-725), 1.2 mm Glass OD
64-1053 E Series with Handle; Wire with 2 mm Jack and Vent (for use with Warner Oocyte Clamp OC-725), 1.5 mm Glass OD
64-1054 E Series with Handle; Wire with 2 mm Jack and Vent (for use with Warner Oocyte Clamp OC-725), 2.0 mm Glass OD
64-0185 Model VC-8P Valve Control System/8 pinch valves
64-0135 Model VC-66CS Complete Pinch Valve System with 6 Valves
64-1940 (DWV) Dedicated Workstation Vacuum
69-0130 Nanoject II Nanoliter Injector, 115 V, 60 Hz, US Plug
64-1586 (BPM-1) Base plate, magnetic steel, 12x24 x 3/8', thick powder coating"
64-1328 WA30-5 1 mm Pin with 30 cm L, 26 ga. Insulated Wire, pkg. of 3
64-0029 725MC Model Cell for Oocyte Clamp
64-1327 WA10-5 1 mm Pin with 10 cm L, .25 mm D Bare Silver Wire, pkg. of 2
64-1289 Pipette Seal for 1.0 m Diameter Glass
64-1290 Pipette Seal for 1.2 m Diameter Glass
64-1291 Pipette Seal for 1.5 m Diameter Glass
64-1292 Pipette Seal for 2.0 m Diameter Glass
64-1298 Wire Seal for E, ME, MP, and Theta Holders
463-1180 Probe handle assembly for OC-725 Series voltage electrode
460-8090 Rack handle (2U)
64-0455 (PV-830) Power Line Conditioner
1000 VA, 120 VAC 60HZ
64-0456 (PV-830CE) Power Line Conditioner 1000 VA, 220 VAC 50/60HZ
64-0031 7250V Replacement Voltage Headstage for Oocyte Clamp
64-0032 7251I Replacement Bath Clamp Headstage for Oocyte Clamp
64-0033 7259C Replacement Current Electrode Cable for Oocyte Clamp
64-0030 7255DI Optional Differential Headstage for Oocyte Clamp
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Fast Stable Voltage Clamping

The OC-725C combines high AC and DC gains and a voltage compliance of ±180 volts to insure fast, non-saturating clamp performance under nearly any condition. The AC clamp gain is variable up to 2000. An additional DC gain of 1 x 106 may be employed for high conductance cells (leaky Oocytes).

Two clamp speeds are available: The Slow mode is used for screening oocytes or for applications not requiring fast response times. The Fast mode is used for accurate voltage clamp of fast whole cell currents. Clamp response time in the Fast mode is 350 µsec (10-90% rise time) when applying a 100 mV step to a model cell.

Improved Bath Clamp Headstage

The current measuring range of the OC-725C bath clamp headstage has been extended at both ends by the addition of a 3 position range multiplier. Smaller currents are amplified to usable levels and larger currents up to 1 mA can be recorded without output saturation. The unique design of the bath clamp eliminates the need for series resistance compensation. It provides an accurate measurement of bath current by creating a virtual ground in the bath while simultaneously clamping the bath potential at zero.

Voltage Headstage Probe

The voltage measuring headstage is a single-ended, high-impedance probe. Its small size, convenient mounting rod and 2 meter cable make for easy attachment to a micropositioner. The headstage input is a 2 mm diameter pin. An electrode holder with a 2 mm jack (supplied) mounts directly on the headstage.

Voltage and Current Meters

Independent meters provide simultaneous displays of membrane voltage Vm and membrane current Im. To assure proper impalement of the current electrode, the current meter displays membrane potential Ve from the current electrode before the clamp circuit is turned on.

Clamp Commands

The internal Hold control is a digital push button control with two ranges; ±1 to 99 mV (x1) and ±2 to 198 mV (x2). Hold can be incremented in steps of 1, 2, 10 and 20 mV for I-V studies. External command signals applied to Command IN ÷10 are attenuated to reduce noise from the command source. Hold and external commands are summed.

Additional Features

  • Buzz controls (1 kHz square wave) for each electrode aid in penetration of cell membranes with a minimum of leakage
  • Overload alarm (audible and visual) indicate when the compliance voltage is exceeded safeguarding the Oocyte and indicating that current records are subject to saturation
  • DC Offsets for both voltage and current electrodes
  • Electrode Test for both electrodes
  • Capacity Compensation for the Vm voltage input

Electrode Holders

Two vented electrode holders with silver wires are typically required with the clamp; a straight type for use with the voltage headstage and a 45° type with mounting handle for use with current electrodes. Vents have been added to the electrodes to prevent pressure build-up inside the electrode which can damage oocytes.

Unvented holders are available and have a 'N' at the end of the model number. Vented holders have a 'V' on the end of the model number. A two meter length cable assembly is provided to connect the current electrode holder to the clamp.

Select the holder based on your glass outer diameter. Holders are available separately.

Dual Oocyte Studies

Some studies, such as voltage control across gap junctions, require the clamping of two oocytes in a common bath using two voltage clamps. The combined currents from the two Oocytes cause problems because the bath clamp headstage cannot separate the individual currents and therefore cannot provide effective clamping.

OC-725C has two features to address these problems:

  • An internal switch permits measurements of the current in series with the current electrode instead of in the bath
  • Optional differential voltage headstages (Model 7255 DI): The differential measurement subtracts the voltage drop across the series resistance in the bath, which is normally eliminated by the bath clamp

Supplied Hardware

The OC-725 is supplied with:

  • 7250V voltage headstage
  • 7251I bath clamp headstage
  • 7259C current cable
  • Model cell, rack mount hardware
  • Specify line operating voltage if other than 100-130 VAC

Purchased separately

  • One straight and one 45º electrode holder is also needed
Test Condition #1 Model cell used to obtain specifications.
Model membrane: 1 MΩ in parallel with 220 nF.
Current and voltage electrodes both 1 MΩ impedence.
Test Condition #2 Noise measurements made with an 8-pole Bessel filter.
Voltage Recording Channel (Vm) V Probe Input Impedance 0.5 x 1012Ω, 1 pF
Output Resistance 100Ω
DC Offset ± 200 mV at input. Variations from zero with 10 turn control (20 mV/turn).
Noise (0-10 kHz) 3 µV RMS with input grounded
20 µV RMS with model cell
Electrode Test 10 mV/MΩ read on meter
100 mV/MΩ at Vm x10 output
Meter Range ± 199.9 mV full scale
Capacity Compensation 0 - 90 pF
Current Sensing Channel (Bath Clamp) (Im) Noise (0-1 kHz) 4.5 nA RMS with bath clamp
10 nA RMS in output leg
I Monitor Output 1 nA/mV to 1 mA/10V in 7 steps and 3 ranges, x0.1, x1, and x10.
Gain Telegraph Output 0.2 to 2.6 V in 7 steps (200 mV/step) and 3 ranges, x0.1, x1, and x10. Compatible with data acquisition software*
Meter Range, full scale Clamp Current: ± 199.9 µA
Electrode Voltage (Ve) ± 199.9 mV; current meter reads Ve when clamp mode switch is off.
Current Electrode Channel Compliance Voltage ± 180 V
Clamp Speed 350 µsec; (10-90%) with 100 mV square wave command applied to model cell
Gain Variable AC/DC: 0 to 2000
Fixed DC Gain Switch selected: 1 x 106
Ve DC Offset ± 200 mV at input (20 mV/turn)
Electrode Test 10 mV/MΩ read on current meter
100 mV/MΩ at Ve x10 output rear panel
Commands Hold Manually set with digital potentiometer, 2 digit resolution and 2 ranges:
x1 range: ± 1 to 99 mV in 1 mV steps
x2 range: ± 2 to 198 mV in 2 mV steps
External Signals applied to COMMAND IN÷10 are attenuated by a factor of 10,
1 V applied = 100 mV command
Physical Dimensions Case 8.9 cm H x 43.2 cm W x 30.5 cm D
Voltage Headstage 12.5 mm D x 5 cm L with 1.8 m cable
Mounting Handle 4.8 mm D x 6.3 cm L
Bath Headstage 2.3 cm H x 3.5 cm W x 4.2 cm L with 1.8 m cable
Shipping Weight 6.8 kg
Warranty Three years, parts & labor
Power Requirements 100-130 V or 220-240 VAC, 50/60 Hz, 20 VA
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OC-725C (070514).pdfOC-725C Manual
Connecting the OC-725 to pclamp (2005.06.24).pdfConnecting the OC-725 to pClamp