Multi-Line In-Line Solution Heaters (SHM-6, SHM-8)

Multi-Line In-Line Solution Heaters (SHM-6, SHM-8)

Multi-line in-line solution heating is the simplest and most effective method of warming multiple perfusion solutions to the same temperature.

  • SHM-6 six-line and SHM-8 eight-line solution heaters
  • Compatible with both single channel TC-324C and dual channel TC-344C heater controllers
  • Temperature of 37°C can be maintained at ± 0.2°C

Item# Description U.S. List Price Quantity
64-0104 SHM-6 Six-Line Solution In-line Heater
64-0105 SHM-8 Eight-Line Solution In-line Heater
64-0107 TA-29 Replacement Cable with Bead Thermistor
64-0108 TA-30 Replacement Cable with Glass Thermistor
64-0755 PE-160/10 Polyethylene Tubing PE-160, 10 ft.
69-0225 MB-B Magnetic Base
64-0564 U9404 3-Prong Clamp
64-2400 TC-324C Heater Controller, Single Channel
64-2401 TC-344C Heater Controller, Dual Channel
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In-line solution heating is the simplest and most effective method of warming
perfusion solutions. TA-30The minimal dead space manifold at the output of the
in-line solution heater allows it to be used in any application where from
2 to 8 perfusion lines are required to be connected to a chamber or other device.

The output from the heater is connected to the chamber using a short length of tubing such that the warmed perfusate flows directly into the chamber bath. Connections are made by press fitting PE-160 tubing onto the 18 gauge stainless steel hypodermic tubes. Cap plugs are supplied to block any unused inputs.

 Depending on bath volume and other factors, inline solution heating itself may be sufficient for many applications. (Solution reservoir heaters from Warner Instruments are recommended if outgassing of solutions is a problem.) The SHM Series heaters will accommodate flow rates up to 5 mL/min while maintaining 37°C.

Each heater is supplied with a TA-29 thermistor cable assembly (shown on the right) which allows for monitoring the actual bath temperature (T2 output on the heater controller), and 3 meters of PE-160 tubing. Both are compatible with Warner's TC-324C and TC-344C temperature controllers.

Heater Resistance 10 Ω
Voltage Requirement Variable 0 to 12 VDC max.
Maximum Temperature 50°C
Internal Dead Volume 94 µL
Manifold Dead Volume 30 µL (manifold input to output)
Maximum Flow Rate at 37°C
SHM-6 5 mL/min
SHM-8 5 mL/min
Physical Dimensions
Body 16.5 mm x 165 (D x L)
Cable 1.9 m
Weight 104 g
Warranty 1 year
Temperature of 37°C can be maintained at ± 0.2°C under following conditions:
Condition A Solution temperature at input (nominally 21°C) varies no more than ±10%
Condition B Solution flow rate varies no more than 25% with 5 mL min/max flow rate
  1. Lack of potentiating effect of increasing temperature on responses to chemical activators in vagal sensory neurons isolated from TRPV1-null mice
    Ni D, Lee LY
    Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L897-904
  2. Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model
    Yao X, Anderson DL, Ross SA, Lang DG, Desai BZ, Cooper DC, Wheelan P, McIntyre MS, Bergquist ML, MacKenzie KI, Becherer JD, Hashim MA
    Br J Pharmacol. 2008 Aug;154(7):1446-56
  3. Dynamics of Somatostatin Type 2A Receptor Cargoes in Living Hippocampal Neurons
    Lelouvier B, Tamagno G, Kaindl AM, Roland A, Lelievre V, Le Verche V, Loudes C, Gressens P, Faivre-Baumann A, Lenkei Z, Dournaud P
    J Neurosci. 2008 Apr 23;28(17):4336-49
  4. Effect of increasing temperature on TRPV1-mediated responses in isolated rat pulmonary sensory neurons
    Ni D, Lee LY
    Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L563-71
  5. Insufficient Sleep Reversibly Alters Bidirectional Synaptic Plasticity and NMDA Receptor Function
    Kopp C, Longordo F, Nicholson JR, Lüthi A
    J Neurosci. 2006 Nov 29;26(48):12456-65
  6. Glial Cell Line-Derived Neurotrophic Factor Family Members Sensitize Nociceptors In Vitro and Produce Thermal Hyperalgesia In Vivo
    Sacha A. Malin, Derek C. Molliver, H. Richard Koerber, Pamela Cornuet, Rebecca Frye, Kathryn M. Albers, and Brian M. Davis
    The Journal of Neuroscience, August 16, 2006, 26(33):8588-8599
  7. Compensatory Responses to Pyruvate Carboxylase Suppression in Islet -Cells
    Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB
    J Biol Chem. 2006 Aug 4;281(31):22342-51
    Shuying Wang
    Submitted to the Graduate Faculty of School of Medicine in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Pittsburgh 2006
  9. Artemin Regulates Nociceptor Responses to Thermal and Chemical Stimuli
    Christopher Michael Elitt
    Dissertation univ of Pittsburgh, 2006
  10. TRPV3 is a calcium-permeable temperature-sensitive cation channel
    Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE
    Nature. 2002 Jul 11;418(6894):181-6
Integrated Components Brochure_06_7_11.pdfIntegrated Components for Live Cell Imaging Brochure
SHM Series (061023).pdfMulti-Line In-Line Solution Heaters (SHM-6, SHM-8) Manual