MicroVent Ventilator for Prenatal Mice (Model 848), Single Animal Volume Controlled

MicroVent Ventilator for Prenatal Mice (Model 848)

The MicroVent Ventilator is a constant-volume respiration pump operating on the Starling principle. Unlike conventional units for larger animals, this ventilator employs a rotary plunger and has no valves. During each ventilation cycle, the plunger performs a synchronized forward and rotating movement. Cleverly arranged bores and channels in the cylinder and plunger control inspiration and expiration during each stroke of the plunger.

  • Ideal for very small animals, perinatal mice, birds 
  • Stroke volume range from 0 to 130 µl 
  • Ventilation rate from 60 to 400 breaths/minute 
  • Simple adjustment of stroke volume while running 
  • Valveless piston pump, no valves to clog 
  • Very small instrument/circuit dead space volume 
  • Compact construction, place close to animal 
  • No vibrations, very low noise .

The extremely light weight and compact construction, in addition to the convenient rod clamp, allow the MicroVent Ventilator to be positioned directly next to the animal.

Item# Description U.S. List Price Quantity
73-3590 MicroVent Ultra-Low Volume Ventilator, Type 848, 230 VAC
73-3591 MicroVent Ultra-Low Volume Ventilator, Type 848, 115 VAC
73-3077 Connection Kit for ISOFLURAN gas anesthesia systems to MiniVent, MicroVent, MidiVent and Model 687 Mouse Ventilators
73-4008 Trigger Output Option for MiniVent, End of Inspiration
73-4013 Tirgger Output Option for Minivent, End of Expiration
73-2731 Tracheal Cannula for Mouse, OD 1.0 mm, L 13 mm, with Y-adapter for Minivent
73-2737 Intubation Cannula with Y-adapter for Mouse, OD 1.0 mm, L 24 mm
73-0027 Silicone Tubing with Mouse Y-Adapter to MiniVent, Pack of 10
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The MicroVent Ventilator is a constant-volume respiration pump operating on the Starling principle. Unlike conventional units for larger animals, this ventilator employs a rotary plunger and has no valves. During each ventilation cycle, the plunger performs a synchronized forward and rotating movement. Cleverly arranged bores and channels in the cylinder and plunger control inspiration and expiration during each stroke of the plunger.

Key Features

  • Ideal for very small animals, perinatal mice, birds 
  • Stroke volume range from 0 to 130 µl 
  • Ventilation rate from 60 to 400 breaths/minute 
  • Simple adjustment of stroke volume while running 
  • Valveless piston pump, no valves to clog 
  • Very small instrument/circuit dead space volume 
  • Compact construction, place close to animal 
  • No vibrations, very low noise


How It Works

The extremely light weight and compact construction, in addition to the convenient rod clamp, allow the MicroVent Ventilator to be positioned directly next to the animal. Typical setups with larger ventilators produce large tubing and instrument dead space volumes. These larger volumes introduce greater system compliance which can affect the accuracy with which the full tidal volume is introduced into the animal's lungs. With the MicroVent, the tidal volume error due to system compliance is reduced to less than 3 µl. Tidal volume and respiration rate can be set exactly to the values required for animal ventilation. The level of precision and control available to the investigator minimizes the danger of hyperventilation or hypoventilation. The tidal volume can be varied continuously from 0 to 130 µl during operation without having to interrupt ventilation. The respiration rate is also continuously adjustable from 60 to 400 strokes/min. The expired air can be recovered at the collection port for sampling, recycling or for the generation of a positive end-expiratory pressure (PEEP). Room air or any non-explosive gas mixture can be used to feed the pump intake.


Components

A multi-gas inlet adapter is available for the MicroVent so that alternate gas mixtures and nebulized substances are delivered to the MicroVent inlet port at atmospheric pressure. The adapter provides ports for multiple selectable gas mixtures (hypoxic, anesthetic...) and a port for the Aerosol Nebulizer.

Specifications

MicroVent Ventilators

Voltage Range
73-3591
73-3590

 115 VAC
 230 VAC
Number of Animals  1
Species  Perinatal mouse, small bird
Control Modes  Volume
Gas Supply  Room air or non-flammable mixed gas
Display  None
IE Ratio,%  1:1
PEEP  Provided via attachment of water column
Respiration Rate, Maximum, breaths/min  400
Respiration Rate, Minimum, breaths/min  60
Repiration Rate Note  Continuously adjustable from 60 to 400 breaths/min
Sigh Frequency  None
Sigh Pressure  Not available
Tidal Volume, Maximum, ml/stroke  0.13
Tidal Volume, Minimum, ml/stroke  0.03 
Stroke Volume   Continuously adjustable from 0 to 130 µl
Weight Range, Maximum, g  50
Weight Range, Minimum, g  1
Dimensions, W x H x D, in (cm) 3.9 x 3.1 x 7.9 (10 x 8 x 20)
Net Weight, lb (kg)  2.2 (1)
AC Adapter Weight, lb (kg)  0.7 (0.3)
Certifications  CE


Cannula

  73-2737
Animal Species  Mouse
Length, mm  28
Note Length listed is total cannula length
OD, mm  1.0
Y-Adapter, mm  3.0

Anne Hilgendorff , Kakoli Parai , Robert Ertsey , Edwin Navarro , Noopur Jain , Francis Carandang , Joanna Peterson , Lucia Mokres , Carlos Milla , Stefanie Preuss , Miguel Alejandre Alcazar , Suleman Khan , Juliet Masumi , Nancy Ferreira-Tojais , Sana Mujahid , Barry Starcher , Marlene Rabinovitch , Richard Bland (2015 ) Lung matrix and vascular remodeling in mechanically ventilated elastin haploinsufficient newborn mice Am J Physiol Lung Cell Mol Physiol

Sergey A. Sosunov, Xavier Ameer, Zoya V. Niatsetskaya, Irina Utkina-Sosunova, Veniamin I. Ratner, Vadim S. Ten (2015 ) Isoflurane Anesthesia Initiated at the Onset of Reperfusion Attenuates Oxidative and Hypoxic-Ischemic Brain Injury PLoS One

Anne Hilgendorff , Kakoli Parai , Robert Ertsey , G. Juliana Rey-Parra , Bernard Thébaud , Rasa Tamosiuniene , Noopur Jain , Edwin F. Navarro , Barry C. Starcher , Mark R. Nicolls , Marlene Rabinovitch , Richard D. Bland (2012 ) Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth Am J Physiol Lung Cell Mol Physiol

Veniamin Ratner1, Sergey A. Sosunov1, Zoya V. Niatsetskaya1, Irina V. Utkina-Sosunova1, and Vadim S. Ten1 (2013 ) Mechanical Ventilation Causes Pulmonary Mitochondrial Dysfunction and Delayed Alveolarization in Neonatal Mice Am J Respir Cell Mol Biol

DOCUMENT DESCRIPTION
Mini_Micro_MidiVent Manual.pdfMicroVent Ventilator (Type 848) User's Manual