Homeothermic Blanket Systems with Flexible Probe

Feedback loop warming system that allows for the animal's temperature to be maintained. Each system is supplied complete with control unit, flexible temperature probe, blanket, and plastic cover for the blanket.

Animal body temperature control at its simplest — feedback loop maintains animal’s temperature
Versatile, offered in two sizes — for mice, rats, cats, or similar sized animals
New lightweight package
Improved electronic circuitry
Suitable with high gain recording equipment
Displays actual body temperature on Control Unit from 20° to 50°C (68° to 122°F)

Additional blankets and spare plastic covers can be purchased separately.

See Full Description for additional information.

Item Listing

Item#	Description	U.S. List Price	Quantity
50-7221F	Complete Homeothermic Blanket System with Flexible Probe, Small, 230 VAC, 50 Hz
50-7220F	Complete Homeothermic Blanket System with Flexible Probe, Small, 115 VAC, 60 Hz
50-7223F	Complete Homeothermic Blanket System with Flexible Probe, Medium, 230 VAC, 50 Hz
50-7222F	Complete Homeothermic Blanket System with Flexible Probe, Medium, 115 VAC, 60 Hz
50-7217	Flexible Probe Only, 1.6mm OD. Contact Technical Support to verify compatability with your system.
50-7214	Small Homeothermic Blanket Only, 20 Watts
50-7215	Medium Homeothermic Blanket Only, 30 Watts
50-7178	Spare Plastic Cover for Small Blankets
50-7194	Spare Plastic Cover for Medium Blankets
50-7210	Spare Plastic Cover for Large Blankets

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Full Description

This homeothermic blanket system is a feedback loop warming system that enables the researcher to maintain an animal’s temperature within the preset range of 20° to 50°C (68° to 122°F).

Each system is supplied complete with a control unit, a flexible temperature probe, blanket, and plastic cover for the blanket. The flexible probe is a precision thermistor encapsulated in a bead of epoxy resin at the top of a flexible hollow plastic tube. The 1.7 mm diameter probe is 100 mm (4 in) long and has a 2 m (6 ft) long cable with plug for attachment to the control unit. It is suitable for a wide range of laboratory animals from mice to cats.

Simple and Easy

Wrap the animal tightly in the heating blanket, using tape if necessary. Insert the temperature-sensing probe rectally, and set the required temperature by means of the control on the front panel.

Should the animal’s core temperature fall, power is automatically increased to the blanket; conversely, power will automatically reduce if the animal’s temperature rises. During this process the animal’s temperature is continuously displayed on a front panel LCD display.

How It Works

The output of the temperature sensing probe is used by the control unit to proportionally control the regulated, low-voltage DC supply to the blanket. This method of control alleviates the interference problems associated with that of non-proportional control, such as switching contacts, thus enabling the system to be used in conjunction with high-gain recording systems.

The control temperature is preset at 37°C (98.6°F) at the factory, but can be adjusted within the range of 20° to 50°C (68° to 122°F) by means of a control on the front panel. An LCD display on the control unit continuously displays the probe temperature. A horizontal LED bar graph indicates the level of power being delivered to the blanket. When core temperature is substantially below the desired temperature the bar graph will indicate maximum power being delivered.

About the Blanket

The blanket consists of a highly flexible insulated heating element, which can be folded without risking internal damage. It is electrically floating, with respect to ground however, one end of the heating element can be grounded by a switch on the front panel of the control unit. The system operates satisfactorily whether or not the blanket is grounded. Special circuitry eliminates electrical noise thus permitting sensitive recordings.

Blankets are available in two sizes:

Small Blanket: Measures 15 x 20 cm (6 x 8 in) and is suitable for rodents
Medium Blanket: Measures 45 x 70 cm (18 x 27 in) and is suitable for rabbits and cats

The blanket is supplied with a 2 m (6 ft) cable attached to a plug for connection to the control unit. Replacement parts are available.

Specifications

Specifications	50-7221F	50-7220F	50-7223F	50-7222F	50-7214	50-7215	50-7178	50-7194	50-7210
Blanket Length English	6	6	18	18	6	18
Blanket Length Metric	15	15	45	45	15	45
Blanket Only Power Watts	8	8	27	27	20	30
Blanket Width English	20	20	70	70	8	27
Blanket Width Metric	6	6	6	6	20	70
Cable Length English	2	2	2	2	6	6
Cable Length Metric	50	60	50	60	2	2
Size	230	115	230	115	Small	Medium	Small	Medium	Large
	Flexible	Flexible	Flexible	Flexible
	1.7 mm	1.7 mm	1.7 mm	1.7 mm
	4	4	4	4
	100	100	100	100
	Precision thermistor encapsulated in a bead of epoxy resin at the top of a flexible hollow plastic tube	Precision thermistor encapsulated in a bead of epoxy resin at the top of a flexible hollow plastic tube	Precision thermistor encapsulated in a bead of epoxy resin at the top of a flexible hollow plastic tube	Precision thermistor encapsulated in a bead of epoxy resin at the top of a flexible hollow plastic tube
	Small	Small	Medium	Medium
	68 to 122	68 to 122	68 to 122	68 to 122
	20 to 50	20 to 50	20 to 50	20 to 50

Journal Articles

Rapid Onset of Specific Diaphragm Weakness in a Healthy Murine Model of Ventilator-induced Diaphragmatic Dysfunction	Segolene Mrozek, M.D., M.Sc.,* Boris Jung, M.D., Ph.D.,† Basil J. Petrof, M.D.,‡ Marion Pauly, M.Sc.,§ Stephanie Roberge, M.Sc.,§ Alain Lacampagne, Ph.D., Ce´ cile Cassan, Ph.D.,# Jerome Thireau, Ph.D., Nicolas Molinari, Ph.D.,†† Emmanuel Futier, M.D., M.Sc.,‡‡ Valerie Scheuermann, M.S.,§§ Jean Michel Constantin, M.D., Ph.D., Stefan Matecki, M.D., Ph.D.,## Samir Jaber, M.D., Ph.D.*	Background: Controlled mechanical ventilation is associated with ventilator-induced diaphragmatic dysfunction, which impedes weaning from mechanical ventilation. To design future clinical trials in humans, a better understanding of the molecular mechanisms using knockout models, which exist only in the mouse, is needed. The aims of this study were to ascertain the feasibility of developing a murine model of ventilator-induced diaphragmatic dysfunction and to determine whether atrophy, sarcolemmal injury, and the main proteolysis systems are activated under these conditions. Methods: Healthy adult male C57/BL6 mice were assigned to three groups: (1) mechanical ventilation with end-expiratory positive pressure of 2– 4 cm H2O for 6 h (n 6), (2) spontaneous breathing with continuous positive airway pressure of 2– 4 cm H2O for 6 h (n 6), and (3) controls with no specific intervention (n 6). Airway pressure and hemodynamic parameters were monitored. Upon euthanasia, arterial blood gases and isometric contractile properties of the diaphragm and extensor digitorum longus were evaluated. Histology and immunoblotting for the main proteolysis pathways were performed. Results: Hemodynamic parameters and arterial blood gases were comparable between groups and within normal physiologic ranges. Diaphragmatic but not extensor digitorum longus force production declined in the mechanical ventilation group (maximal force decreased by approximately 40%) compared with the control and continuous positive airway pressure groups. No histologic difference was found between groups. In opposition with the calpains, caspase 3 was activated in the mechanical ventilation group. Conclusion: Controlled mechanical ventilation for 6 h in the mouse is associated with significant diaphragmatic but not limb muscle weakness without atrophy or sarcolemmal injury and activates proteolysis.