The Randall & Selitto test is based on determination of the animal threshold response to pain induced in the paw by the application of a uniformly increasing pressure.

In the LE7306 paw-pressure, a stimulation unit allows the gradual increase (at selectable rates) of the pressure applied on the animal paw. The pressure increase is achieved by a step-motor inducing the progressive advancement of a sliding support with a distal conic tip (1 mm diameter).

The conic tip is mounted on an extensiometric load cell, making possible the visualization on the digital display of the current force applied at each moment of the test (grams). The motor and tip units are mounted on a pivoting stand preventing any excess pressure on the animal paw.

The Control Unit makes possible the adjustment of the force transducer, balance and reset, as well as the selection of the step-motor current speed.

A remote foot-switch controls the motor turn on/off allowing rapid hands-free experiments. An automatic system is activated once the distal extreme of the sliding support track is reached or when the pedal is released at the test ending point. Then, the motor reverse its rotation at its higher speed, sliding up the conic tip again.

SeDacom software supplied with the unit can be used to automatically record the results on a PC through a RS-232 port.

Citations
Célérier E et al. (2006) Opioid-induced hyperalgesia in a murine model of postoperative pain: role of nitric oxide generated from the inducible nitric oxide synthase. Anesthesiology 104(3): 546-555. (Paw-pressure, Mice, Spain)
Célérier E et al. (2004) Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase C-gamma gene. Neuropharmacol. 46:264-272. (Tail-pressure, Mice, Spain)
Martin M et al. (2003) Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones Eur. J. .Neurosci. 17(4):701 (Tail-pressure, Mice, Spain)
Kim HW et al. (2002) The antinociceptive properties of Ethylacetate extracts from Bang-Poong (Radix Ledebouriellae) on the FreudŐs Adjuvant-Induced Arthristis in Rats. J. Vet. Sci. 3(4): 343-9. (Rats, South Korea).
Kwon YB et al. (2002) The water-soluble fraction of bee venom produces antonociceptive and anti-inflammatory effects on rheumatoid arthritis in rats. Life Sciences 71: 191-204 (Rats, South Korea)
Kwon YB et al. (2001) Bee venom injection into an acupuncture point reduces arthritis associated oedema and nociceptive responses. Pain 90 (2001) 90(3):271-80 (Rats, South Korea)
Lee JH et al. (2001) Bee venom pretreatment has both an antinociceptive and anti-inflammatory effect on carrageenan-induced inflammation. J Vet Med Sci. 63(3):251-9. (Rats, South Korea)