Announcing our enhanced Inspira ventilator family:

• Inspira Advanced Safety Ventilator — Volume Controlled (ASVV )
• Inspira Advanced Safety Ventilator — Pressure Controlled (ASVP )
• Inspira Advanced Safety Ventilator Inspiratory Hold — Volume Controlled (ASVV-IH)
• Inspira Advanced Safety Ventilator Inspiratory Hold — Pressure Controlled (ASVP-IH)

Our Inspira ventilators are the result of extensive research and development. Each features an easy to use keypad, bright display, and all gas ports located on the front panel. Advanced functions include Airway Pressure Monitoring, Assist Mode, Programmable Sigh Breaths, and Adjustable I:E Ratio.

Call Harvard Apparatus for more details. One Ventilator — Many Animals

This is Harvard Apparatus' first ventilator that can ventilate animals from mice to cats using the same machine. It provides respiration rates from 5 to 200 bpm. The tidal volume is adjustable from 0.1 ml to 100 ml. It is no longer necessary to purchase one ventilator for mice and another for large rodents. The Inspira can do it all.

Easy to Use
Simply enter the animal's weight and press run! A microprocessor recommends the respiratory profile for a user-entered animal weight. The user may override respiratory parameters if needed. The ventilators have a bright, easy-to-read display and simple to use keypad.
All gas connections are positioned on the front of the machine for convenience. In addition to the gas ports, two analog outputs, an external trigger connector, and sync out connector are also located on the front of the machine. An RS-232 port is located on the back of the machine and can be used for remote control, data logging, or printer connection.

Airway Pressure Monitoring
Built-in pressure sensor monitors airway pressure. Under and over pressure limits are monitored. Starting limits are selected by built-in controller.

Safe Range™
Setting up the ASV ventilators is both easy and safe thanks to the Safe Range™ software. Once the animal's body weight has been entered the software computes the median settings for tidal volume and respiratory rate. These same equations are used to calculate a Safe Range™ around the median values. All the default parameter settings can be overridden. If you enter a setting outside of the Safe Range for the body mass of the animal to be ventilated you are warned that the value is outside the Safe Range™ and asked to confirm the setting.

Bright & Easy to Read Display
This new display has two lines each with 20 characters. Both the respiration rate and tidal volume are brightly displayed simultaneously.

Membrane Keypad
The new keypad is simple and intuitive. Respiration rate, tidal volume, animal weight, sigh breath, I:E ratio, and pressure limits are all accessed directly via a button on the keypad. For customized ventilation protocols, simply press the ‘SET' button and then the desired button to enter the required value on the numeric keypad. Pressing the ‘ENTER' button inputs the value.

Two RS-232 Ports
The rear of the machine has two RS-232 ports for remote control, data logging, or printer connection and also User I/O. To the side of the machine there is a window allowing the user to view piston motion.

Assist Mode
Both the volume and pressure controlled ventilators support an Assist Mode. This feature helps to wean the animal off the ventilator. When the animal attempts to initiate a breath on its own, a pressure sensor detects the drop in lung pressure. This drop initiates a ventilation cycle.

The sensitivity of the Assist Mode is adjustable from —1 to —10 cmH2O. The ventilator lets the animal initiate breaths independently as long as its breathing rate is greater than the respiration rate set by the user or calculated by the microprocessor.

Sigh Breath
With continuous, long term ventilation and the force of gravity, the animal's lungs begin to collapse. Introducing a larger than normal tidal volume over inflates the animal's lungs, periodically replicating the natural sigh. It allows the lungs to expand and opens the collapsed alveoli. The frequency of the sigh breath is user selectable and available in both the ASVV and the ASVP models.
For both ventilators, the sigh breath information is entered via the keypad. For Inspira ASVV, the user enters a sigh breath volume. With the Inspira ASVP, the user enters a sigh breath pressure. For both ventilators the sigh breath frequency may be programmed which automatically initiates sigh breaths. These breaths may also be triggered manually by pressing the SIGH button on the keypad during respiration.

Volume-Controlled vs. Pressure Controlled
The Inspira ASVV delivers the desired tidal volume to the animal by precisely controlling the stroke of the piston. Stroke speed is controlled during inspiration and expiration allowing variable inspiration-to-expiration ratios.
The Inspira ASVP delivers gas during inhalation by moving the piston while continuously monitoring the airway pressure. The microprocessor reads the increasing pressure and compares it to the maximum inspiration pressure set by the user. When the maximum pressure is reached, the piston stops. The exhale valve opens at the appropriate time determined by % inspiration time and closes when the PEEP (positive end expiratory pressure) setting is reached.

Inspiratory Hold
The newest addition to the Inspira family offers an Inspiratory Hold feature. This feature is available in both the volume and pressure controlled models. The user can enter the desired hold time and initiate the hold simply by pressing the "Inspiratory Hold" button on the keypad. Standard models can be upgraded to Inspiratory Hold models - please contact our technical support department for additional details.

PEEP - Positive End Expiratory Pressure (Inspira ASVP Only)
The Inspira ASVP also has a PEEP feature. This feature allows a positive pressure to be maintained between inspirations instead of falling to zero or near zero at the end of the expiratory phase. When the PEEP pressure is reached, the expiration valve closes until the next inspiration cycle begins. This allows the lungs to maintain a positive pressure through most or all of the breathing cycle which is a more natural state for the lungs.

Piston/Cylinder Assembly
The Inspira Ventilators use a glass and graphite piston/cylinder assembly and a microprocessor controlled actuation mechanism to precisely control respiration profiles. Two easily interchangeable piston/cylinder assemblies are available to provide 0.1 ml to 10 ml and 10 ml to 100 ml tidal volumes. Changing the piston/cylinder assembly is simple. Open the top chassis cover, unscrew the assembly, and install the new piston/cylinder assembly. The ventilator automatically detects which size cylinder is installed. Variable flow valves control the inhalation and exhalation gas flow. A window shows the piston/cylinder assembly at work inside!

Anesthetic Ventilator
Both Inspira ventilators can be used with anesthesia machines to deliver non-flammable anesthetic gases such as Nitrous Oxide, Enflurane, Sevoflurane, Halothane or Isoflurane. A future option for the Inspira ASVV and ASVP ventilators will be anesthetic agent monitoring for Nitrous Oxide, Enflurane, Sevoflurane, Halothane or Isoflurane. Please call Harvard Apparatus for more information.