The LE7406 Hot-Plate performs rapid and precise screening of analgesic drug properties on small-laboratory animals according to the ‘hot-plate test’. The animal's pain sensitivity alterations induced by a specific experimental context change and/or genetic manipulations can also be evaluated through this method.

The hot-plate test, initially described by N.B. Eddy and D. Leimbach (1953), evaluates thermal pain reflexes due to footpad contact with a heated surface. During the experiments, the animal is confined in a removable clear acrylic cylinder where the latency time to the first hind paw or/and jumping responses are measured.

In the LE7406 Hot-Plate, a thick aluminium plate (10 mm) provides a high temperature stability and even surface distribution. The plate temperature can be held at a set point between 45 and 62ºC (± 0.1ºC) by multiple proportional feedback circuits that minimize overshoot. A built-in timer activated by an external foot switch allows precise measurement of reaction time (0.1 sec precision). A remote foot-switch controls the test start/stop allowing rapid hands-free experiments. The operator can read the animal reaction time from the display or from a PC computer using the SeDaCom software. Trial number, plate temperature and reaction time are then sent to the PC through a RS-232 port.

Citations
Camarasa J et al. (2006) Association of caffeine to MDMA does not increase antinociception by potentiates adverse effects of this recreational drug. Brain Res. 1111:72-82. (mouse, Spain)
Grillet N et al. (2005) Generation and characterization of Rgs4 mutant mice. Mol. Cell. Biol. 25(10): 4221-4228. (mice, France)
Kim EJ et al. (2005) Safety pharmacology of sibutramine mesylate, an anti-obesity drug. Hum. Exp. Toxicol. 24(3): 109-119. (Rat, South Korea)
Feria MM et al. (2003) Coexistence of Two Distinct Diurnal Rhythms in Latency of Licking and Jumping Responses in Mice Hot Plate Tests. Biological Rhythm Res. 29(3):260 Đ 271 (Mice, Spain)
Shaheen HM et al. (2000) Effect of Psidium guajava leaves on some aspects of the central nervous system in mice. Phytotherapy Res. 14(2):107-111 (Mice, United Arab Emirates)