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Home Isolated Organ & Isolated Tissue HSE Tissue Superfusion Systems Superfusion Cascade Bath System


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Superfusion Cascade Bath System

The Superfusion Cascade Bath permits testing of extremely small quantities of pharmaceuticals. Any metabolites or mediators released are passed to the subsequent test preparation and can become effective there. It is possible to test up to four preparations (muscle strips or isolated tissues). The preparations are contained in a thermostated chamber. A roller pump produces a small flow of solution (1 - 10 ml/min) which is warmed by a heat exchanger then drips on to the uppermost test preparation. There is a provision for switching between two different solutions. The effluate of each preparation passes in the form of a cascade onto the subsequent preparation. Any muscle contractions produced are measured by force transducers (isometric contraction measurement) or displacement transducers (isotonic contraction measurement).
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739923 Superfusion Cascade Bath System Yes -- View Pricing
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• Applications:
– Evaluation of metabolites or mediators released on subsequent tissues in the fluid cascade
– Detection of substances affecting the smooth musculature (prostaglandins, bradykinin, angiotension II...)
• Suitable for colon, bladder, ileum, duodenum, aortic strips...
• Low volume superfusion is useful when only small quantities of drugs are available
• No contact with glass, surface-active substances cannot be absorbed on the glass surface and contaminate results

The Superfusion Cascade Bath permits testing of extremely small quantities of pharmaceuticals. Any metabolites or mediators released are passed to the subsequent test preparation and can become effective there. It is possible to test up to four preparations (muscle strips or isolated tissues). The preparations are contained in a thermostated chamber. A roller pump produces a small flow of solution (1 - 10 ml/min) which is warmed by a heat exchanger then drips on to the uppermost test preparation. There is a provision for switching between two different solutions. The effluate of each preparation passes in the form of a cascade onto the subsequent preparation. Any muscle contractions produced are measured by force transducers (isometric contraction measurement) or displacement transducers (isotonic contraction measurement).
The Superfusion Cascade Bath, as modified by SCHULER, consists of a moist acrylate chamber which is thermostated by radiant heat from a thermostated metal plate. Temperature control is provided by a thermostatic circulator. The four tissues are arranged in cascade so that each tissue receives its superfusion solution from the previous tissue through a small tube. These stainless steel tubes carry a ring to which the tissues are attached. Part of the tube is in the form of an open channel. The tubes can be moved in height (vertically) and also horizontally, ensuring optimum adjustment to suit the suspended tissues and allows superfusion free from any interruption. Mounting the tissues is simplified by the removable front panel of the chamber.


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Displaying 1 to 10 of 22results for Superfusion Cascade Bath System   Page 1  2  3 

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100% Login to view HS03F3 Potassium channal inhibition in coronary arteries.pdf
[536 KB]
Force Displacemen Transducer, 5-hydroxytryptamine is a mediator of 4-aminopyridine induced contractions in porcine and human isolated coronary arteries
98% Login to view HS19 Organ Bath.pdf
[259 KB]
Organ Bath use in Aging and Chronic Hypertension Decrease Expression of Rat Aortic Soluble Guanylyl Cyclase
84% Login to view WR04PL 1.PDF
[495 KB]
Two Distinct Ca2+ - Dependent Signaling Pathways regulate the Motor Output of Cochlear Outer Hair Cells with Pneumatic Injection System
83% Login to view HS02IS Evaluation of Skeletonized LITA.pdf
[228 KB]
Isolated Organ Set use in Intraoperative and Laboratory Evaluation of Skeletonized Versus Pedicled Internal Thoracic Artery
83% Login to view HS19 Soluble Guanylyl Cyclase in Aging and Hypertension.pdf
[238 KB]
hy010000043p
83% Login to view HS01 Opioids and Coronary Vascular Tone.pdf
[138 KB]
Force Transducer influence of opioids on the vascular tone of isolated porcine coronary artery segments
77% Login to view OT31.pdf
[673 KB]
Development of a multiplexed microbioreactor system for high throughput bioprocessing
75% Login to view Regulate the Motor Output of Cochlear Outer Hair Cells.PDF
[504 KB]
Two Distinct Ca2+ - Dependent Signaling Pathways regulate the Motor Output of Cochlear Outer Hair Cells with Pneumatic Injection System
64% Login to view Permeation and Activation of the M2 Ion Channel.PDF
[248 KB]
Permeation and Activation of the M2 Ion Channel of Influenza A Virus with use of Fast Step Perfusion System
60% Login to view WR19FA 1.PDF
[220 KB]
Permeation and Activation of the M2 Ion Channel of Influenza A Virus with use of Fast Step Perfusion System
   

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Manuals Back to Top

Displaying 1 to 1 of 1result for Superfusion Cascade Bath System  

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100% Login to view metric system trivia.pdf
[146 KB]
Microsoft Word - Lesson1.doc
   

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