The Metabolic Chamber Rack is designed to hold up to 15 individual Metabolic Chambers for Mice. The unique design allows easy insertion and removal of the cages by placing each chamber through a large diameter hole in the rack shelf. The base of the chamber is supported by a solid shelf. The solid base support shelf incorporates a safety plate with large diameter openings to also accept the chamber base. This design feature provides stability for the chambers with out requiring any complicated holding devices or clamping mechanisms. The chambers are simply inserted or removed from the rack as easily as placing a peg in a hole.