The Metabolic Chamber for Mice is designed to house individual mice for 24 hour periods or longer for the purpose of studying the animal’s metabolic function or effects of intervention on the animal’s metabolism. These include, but are not limited to, daily food and water intake, effects of different drug therapies, urinary protein excretion and renal function studies. This Chamber is specifically designed to accurately separate urine from feces for analysis. The chamber is an isolator unit that conforms to the housing specifications in the Guide for the Care and Use of Laboratory Animals.
The Chamber is constructed of gas sterilizable acrylic and all connections are sealed with O-rings. The lid holds a disposable air filter pad. The urine/feces separation cone is stainless steel as are the floor and filter screens. The urine collection vessel is removable and disposable. The chamber is therefore suitable for use in barrier facilities. These chambers are actively used in research projects which have been reported in presentations at national scientific meetings. The chambers have proven to be particularly useful for research involving transgenic mice which must be housed individually for phenotyping and metabolic studies. 72-7060 Metabolic Chamber is Supplied With:
72-7061 Stainless Steel Funnel Assembly
72-7062 Stainless Steel Screen Floor
72-7063 Assembly Cage Lid
72-7064 Acrylic Food Holder Assembly
72-7065 Acrylic Water Bottle Assembly
72-7066 Urine Collection Vessel
Publications
1. Flemming ER, Athirakul K, Oliverio MI, Key M, Goulet J, Koller BH, Coffman TM. Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2. Am J Physiol 1998; 275:F955-61.
2. Oliverio MI, Delnomdedieu M, Best CF, Li P, Morris M, Callahan MF, Johnson GA, Smithies O, Coffman TM. Abnormal water metabolism in mice lacking the type 1A receptor for angiotensin II. Am J Physiol (Renal Physiology) 2000; 278:F75-82.
3. Oliverio MI, Best CF, Smithies O, Coffman TM. Regulation of sodium balance and blood pressure by the AT1A receptor for angiotensin II. Hypertension 2000; 35:550-4.
4. Pace AJ, Lee E, Athirakul K, Coffman TM, O’Brien DA, Koller BH. Failure of spermatogenesis in mouse lines deficient in the Na+-K+-2Cl- cotransporter. J Clin Invest 2000; 105:441-50.
5. Athirakul K, Kim H-S, Audoly LP, Smithies O, Coffman TM. Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition. In Press, Kidney Int.
*Note: The above listed publications reference a “specially constructed” metabolic cage. This cage is the Metabolic Chamber for Mice listed above.