CBAS™ Long-Term Heparin Coating
The Carmeda BioActive Surface (CBAS™) is the product of Carmeda AB in Stockholm, Sweden. Carmeda has an extensive bibliography of CBAS™ applications, particularly in human-use devices. CBAS™ applications in humans include central venous catheters, coronary stents, ventricular assist devices, extracorporeal blood circuits, blood sampling devices, and vascular grafts. CBAS™ is used to coat devices from J&J, Medtronic, and Gore. In lab animal research, CBAS™-coated catheters are used for arterial and venous access. Also, CBAS™ provides dramatic improvement in catheter patency for chronic lymphatic access.
How It Works
CBAS™ is a patented process for applying heparin to the surfaces of biomaterials. Unlike TDMAC heparin, the CBAS™ covalent bonds last several months. The “active sequence” of the heparin molecule serves to halt the clotting cascade.
The endothelial lining of blood vessels contains a heparin-like substance which performs like CBAS™. The novel aspect of CBAS™ is that the active sequence remains available over and over to bind with antithrombin. No other coating can achieve this long-term function.
CBAS™ is the most respected thromboresistant coating available in the human-use medical device industry. It is under license for use in laboratory animal research applications. Unlike hydrogels, CBAS™ is bioactive, not passive. It has been proven repeatedly to minimize the thrombogenecity of intravascular devices.
Long-Term, Non-Leaching
CBAS™ is not consumed. The heparin "active sequence" repeatedly binds to antithrombin to prevent clotting. As such, half-life is not an issue. CBAS™ is "end-point attached" to the catheter surface and does not elute into the bloodstream.
1) CBAS™ heparin "active sequence" is available to bind with antithrombin.
2) Antithrombin conforms to accelerate binding with thrombin and other coagulation factors.
3) Coagulation effect of thrombin is neutralized by formation of thrombin-antithrombin complex.
4) Thrombin-antithrombin complex washes away. CBAS™ heparin “active sequence” remains intact and is available repeatedly to bind with antithrombin.
Reduces Infections
Human clinical studies using CBAS™ and other heparin coatings document a clear anti-infective benefit from heparin coatings. While heparin is not an antimicrobial per se, it does remove the blood nidus for microorganisms thereby minimizing the nutrients and binding sites for many of the unfavorable blood proteins. Appelgren et al demonstrated a 50% reduction in infections from CBAS™ coated catheters in humans. Visit www.carmeda.com for additional information and complete CBAS™ bibliography (200+ references). • Most thromboresistant material
• Rounded distal tip is less traumatic to intimal lining of blood vessels
We offer a full range of silicone, polyurethane and heparin coated polyurethane catheters in sizes for all species. With nearly 20 years of experience designing and manufacturing laboratory animal catheters, we can help you choose the the ideal catheter for your application.
Biomaterials
Silicone rubber continues to be the most popular catheter material; however, polyurethanes have been proven to be more hemocompatible than silicone. The CBAS™ heparin-coated polyurethane has proven to be the most thromboresistant of all available technologies.
Rounded Tips
We recommend rounded tips for intravascular catheters as they are less traumatic to the intimal lining of blood vessels. The sharp edges on square-cut or bevel-cut catheters can irritate the vessel's intimal lining and hasten the host's thrombogenic response.
Additional catheter options include retention beads, suture flanges, depth markings, and special holes and slits for organ perfusion, bladder and gastro-intestinal catheterization.