UP-100IH CORE SYSTEM, BASIC, 230V, 73-4385
The UP-100IH is the preferred system for compound screening that requires the basic measured parameters such as simple Left Ventricular Pressure (IsovolumetricLVP), ECG Lead II measurements, and temperature.Therefore the more common configuration of this system will be the UP-100IH Basic which allows the researcher to measure 2-3 parameters in addition to those that are included in the standard system (Aortic Pressure and LVP). Most researchers will also want to operate in a constant pressure perfusion mode and measure coronary flow, which is a simple addition to the basic system.
The UP-100IH Advanced system allows up to the full range of available measured parameters beyond the basic system including direct coronary flow, ECG lead II, temperature measurement, and metabolic parameters (pH, pO2, pCO2). All UP-100IH systems can be used for constant pressure or constant flow perfusion of isolated hearts of mice, guineapigs, rats and newborn rabbits as long as the coronary flow is below 50 ml/min. Constant pressure perfusion is achieved by the optional addition of a controller (SCP) which modulates the flow generated by the perfusion pumpbased on a perfusion pressure feedback loop. The controller also provides an accurate, low-cost way to indirectly measure coronary flow. The system can be adapted for direct, real-time coronary flow measurement allowing the study of myogene autoregulation (reactive hyperemia) if required. Whether you are isolating cardiomyocytes following a physiology experiment or require occasional cardiomyocyte isolation in addition to the standard Langendorff assays, the Cell Isolation option to the UP-100IH will satisfy your requirements. Other useful add-ons include drug addition using a syringe pump and pacing. If perfusate containing albumin or erythrocytes is used, the oxygenation can be optimized with the addition of a fiber oxygenator. The complete system includes virtually everything you need to accomplish the basic Langendorff experiment, only requiring the addition of the appropriate species-specific package and the desired data acquisition system. Contact our expert technical team if you need assistance with system configuration, application support or custom design requests.
If your chosen options require more than 10 Slot Units you will need to choose the UP-100IH Advanced system
For a working unit, the core system requires the addition of a selection of one of the options UP-MOUSE or UP-RAT/GP.