Tail Suspension Test

Tail Suspension Test

The automatic tail-suspension test allows a fast and reliable screening of the psychotropic properties (anti-depressants, sedatives) of drugs.

  • Up to 6 mice at the same time
  • Automatic measurement of immobility of suspended mouse
  • Capable of automatic randomization
  • Reanalysis enhanced, immobility threshold can be readjusted
  • Direct exportation of the results into Excel
  • Calculates energy and power in motion

Item# Description U.S. List Price Quantity
76-0490 Set of 3 Boxes, Including Transducers and Electronic Elements
76-0492 Interface and Software for Tail Suspension Test
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• Fast evaluation of antidepressive, psychotropic drugs

• Up to 6 mice at the same time

• Automatic measurement of immobility of suspended mouse

• Capable of automatic randomization

• Reanalysis enhanced, immobility threshold can be readjusted

• Direct exportation of the results into Excel®

• Calculates energy and power in motion

The automatic tail-suspension test allows a fast and reliable screening of the psychotropic properties (anti-depressants, sedatives) of drugs.



Basically, the measuring principle is based on the energy developed by mice trying to escape from their suspension. During the test, the movements of the mice are analyzed in terms of force, energy and power developed over time.



The system includes the suspension cages (3 mice per cage) and a user-friendly software to run, record, analyze and replay the experiments. The results are either printed or stored in .txt or.xls files formats.



Citations

Alexandre C et al. (2006) Early Life Blockade of 5-Hydroxytryptamine 1A Receptors Normalizes Sleep and Depression-Like Behavior in Adult Knock-Out Mice Lacking the Serotonin Transporter. J. Neurosci. 26(20): 5554-5564. (mouse, France, Germany)

Cryan J et al. (2004) The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci. Biobehav. Rev. 29(4-5):571-625. (mouse, Switzerland)

Mombereau C et al. (2004) Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior. Neuropsychopharmacol. 29:1050-1062 (mouse, Stwitzerland)

Strekalova T et al. (2004) Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming and Exploration. Neuropsychopharmacol., 29(11):2007-17 (mouse, Germany).
Specifications76-0490
Catalog PagesG57
Computer RequirementsWindows XP, One free PCI Slot Required
Material CompositionBlack and White Perspex, metal hook
Maximum Number of Stations6 Stations Per Computer
Model NumberBSTST2CA
Power Requirements110/220V, 50/60 Hz