Tail Suspension Test

Tail Suspension Test

The automatic tail-suspension test allows a fast and reliable screening of the psychotropic properties (anti-depressants, sedatives) of drugs.

  • Fully automatic and operator-independent
  • Includes 4 types of randomization processes of the animal list
  • Measurement of up to 6 animals in the same run
  • Full control of the calibration
  • High predictability for antidepressant effects in humans
  • Based on innate behaviours and despair models
  • Widely used in literature and deeply validated in phenotyping and pharmacology
  • Simple to set up and use
  • Replay possible with other parameters
  • Short-lasting experiment (usually 6 minutes)
  • Optional video recording to adjust the activity threshold

Item# Description U.S. List Price Quantity
76-0780 (BIO-TST4) Automated tail suspension test. 1 set of 3 cages for mice with software
76-0781 (BIO-TST-CAGE) 1 additionnal set of 3 cages
76-0782 (BIO-TST-VID) Optional USB video camera with its optic and stand to record suspension and adjust threshold
76-0783 (BIO-TST-UPG) Tail suspension test upgrade to version 4 (for usb based cages only)
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The automatic tail-suspension test allows a fast and reliable screening of the psychotropic properties (anti-depressants, sedatives) of drugs.

  • Fully automatic and operator-independent
  • Includes 4 types of randomization processes of the animal list
  • Measurement of up to 6 animals in the same run
  • Full control of the calibration
  • High predictability for antidepressant effects in humans
  • Based on innate behaviours and despair models
  • Widely used in literature and deeply validated in phenotyping and pharmacology
  • Simple to set up and use
  • Replay possible with other parameters
  • Short-lasting experiment (usually 6 minutes)
  • Optional video recording to adjust the activity threshold
Basically, the measuring principle is based on the energy developed by mice trying to escape from their suspension. During the test, the movements of the mice are analyzed in terms of force, energy and power developed over time.

The system includes the suspension cages (3 mice per cage) and a user-friendly software to run, record, analyze and replay the experiments. The results are either printed or stored in .txt or.xls files formats.

Citations

Alexandre C et al. (2006) Early Life Blockade of 5-Hydroxytryptamine 1A Receptors Normalizes Sleep and Depression-Like Behavior in Adult Knock-Out Mice Lacking the Serotonin Transporter. J. Neurosci. 26(20): 5554-5564. (mouse, France, Germany)

Cryan J et al. (2004) The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci. Biobehav. Rev. 29(4-5):571-625. (mouse, Switzerland)

Mombereau C et al. (2004) Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior. Neuropsychopharmacol. 29:1050-1062 (mouse, Stwitzerland)

Strekalova T et al. (2004) Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming and Exploration. Neuropsychopharmacol., 29(11):2007-17 (mouse, Germany).
Specifications76-0780
Number of animals1-3 mice if one set of cages is used, 1-6 mice if 2 sets of cages are used
Material CompositionBlack and white PVC
Power110-230 Volts- 9 volts DC
Dimensions50 x 15 x 30 cm for a set of three cages
Acquisition sampling rate200 Hz for the sensors, 15 images/second for the camera
PC RequirementsOS: Windows 7 / 8, 32 64 bits, CPU: Intel Core i3, 2.4GHz or equivalent, RAM: 3Go, USB: USB 2 / USB 3, Display resolution: 1152x768 pixels, 1 free USB port / cage set + 1 free USB port for the camera, Compatible with touch-screen tablet using W8