Remote Infuse/Withdraw PHD ULTRA™ 4400 Programmable Syringe Pumps

Remote Infuse/Withdraw PHD ULTRA™ 4400 Programmable Syringe Pumps

The PHD ULTRA™ 4400 is the solution for your most demanding fluidics applications. This pump represents the latest technology in syringe pumps and was developed utilizing the feedback of the world's largest populations of syringe pump users.

The PHD ULTRA™ 4400 will change the way you think about syringe pumps. There are three major areas which make the PHD ULTRA™ 4400 the new standard for syringe pumps:

1. Superior mechanical drive mechanism and syringe holding mechanics to achieve the highest performance of any syringe pump

2. EZ PRO Software and user interface allow easy programming of methods from simple to complex, all without the use of a PC
- Preprogrammed methods for simple to complex operations that allow you to be up and running with the push of a button
- LCD, high resolution color touch screen for powerful functionality, yet easy to use

3. Multiple levels of versatility
a. Configurations: standard and remote
b. Connectivity: RS-232 and USB for PC Control; RS-485 for daisy chaining

Please follow this link for syringe options.

Please follow this link for tubing and connector options.

Item# Description U.S. List Price Quantity
70-3310 PHD ULTRA™ 4400 Remote Syringe Pump Infuse/Withdraw Programmable
70-3030 PHD ULTRA™ RS-232 RJ-11 Connectors Option (If needed, must be purchased at the same time as the Ultra Pump)
70-3033 PHD ULTRA™ Analog Control Input Option (If needed, must be purchased at the same time as the PHD ULTRA™ Programmable Pump)
70-3034 PHD ULTRA™ Internal Fan Option (Required if external operating ambient is >35°C. If needed, fan must be purchased at the same time as the PHD ULTRA™ Pump)
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Features:
• Superior drive mechanism for unmatched smooth flow, accuracy and precision
• From picoliter to 216 ml/min flow rates
• Advanced programming for true multi methods without a PC
• Quick start methods
• Alpha/numeric keyboard without a PC
• Real and relative time clocks
• Icon operation
• New color LCD touch screen
• Up-front control knobs for ease of operation
• Vertical or horizontal orientation
• Adjustable linear force to 200 lbs across the entire flow range
• Daisy chain
• Remote configuration placement
• CE, ETL (UL, CSA), WEEE, EU RoHS, & CB Scheme
• 2 year warranty

Applications:
• Nanofluidics
• Drug/Nutritional infusions
• Electrospinning
• Reaction chamber addition
• Viscous Solutions
• High Pressure Injection
• Highly Corrosive Fluids
• Fluid Blending
• Flow programming
• Gradients
• % composition step changes
• Large flow deliveries
• I/O interactive experiments
The PHD ULTRA™ 4400 is the solution for your most demanding fluidics applications. This pump represents the latest technology in syringe pumps and was developed utilizing the feedback of the world's largest populations of syringe pump users.

The PHD ULTRA™ 4400 will change the way you think about syringe pumps. There are three major areas which make the PHD ULTRA the new standard for syringe pumps:

1. Superior pending mechanical drive mechanism and syringe holding mechanics to achieve the highest performance of any syringe pump

2. EZ PRO Software and user interface allow easy programming of methods from simple to complex, all without the use of a PC
- Preprogrammed methods for simple to complex operations that allow you to be up and running with the push of a button
- LCD, high resolution color touch screen for powerful functionality, yet easy to use

3. Multiple levels of versatility
a. Configurations: standard and remote
b. Connectivity: RS-232 and USB for PC Control; RS-485 for daisy chaining

Harvard Apparatus introduces the next generation of syringe pumps, the PHD ULTRA™ 4400 for the most demanding applications.

Since 1901 Harvard Apparatus has been supporting bioresearch fluidics requirements with the culmination being the introduction of the first commercial syringe pump for bioresearch in 1956. Since 1956, over 70,000 satisfied syringe pump users around the world have made Harvard Apparatus syringe pumps the worlds #1 choice.

The PHD ULTRA™ Syringe Pump series is a family of high-accuracy, microliter- and milliliter-compatible pumps designed for versatile technical use including mass spectroscopy, calibration, drug and nutritional infusions, microdialysis, dispensing, chromatography and LC/HPLC.

Highest Accuracy and Precision
The PHD ULTRA™ 4400 syringe pump family has a new patent pending fluidics drive mechanism which assures ease of use and high performance, for smoother, more accurate flow rates than any other syringe pump. Flow rates are accurate within 0.35% and reproducibility within 0.05%. A microprocessor-controlled, small step angle stepping motor drives a lead screw and pusher block. Advanced micro-stepping techniques are employed to further reduce the step angle to eliminate flow pulsation.

Advanced Programming Features:
• Flow Programming - Change the flow with time, volume or a triggered event as many times as you like
• Bolus - Inject a drug (or drugs) in a high quantity at once. The bolus injection can be made in time or volume.
• Concentration Delivery - Calibrate flow in concentration units of mg/kg easily so flow is calibrated to concentration of drug and animal weight.
• Gradients
• % ratio - up to three solvents
• I/O — dedicated and user defined I/O
• Pulsed Flow- so you can program the pulse easily

Widest Flow Rate Range
This pump is engineered to provide flow accuracy within 0.35% and reproducibility within 0.05%. A Single syringe from 0.5 µl to 140 ml pumps at a range of 3.06 pl/min to 216 ml/min.

Maximum Experimental Versatility
The PHD ULTRA™ 4400 features true Multi-Pump Operation. The pump can be oriented vertically or horizontally for optimum experimental connectivity. This pump comes standard to hold 1 syringe.

Easy-to-Use Interface
The PHD ULTRA™ 4400; color LCD touch screen graphic interface is divided into three basic areas: Operations Display, Message Area, and Navigation. This configuration allows you to easily move through all menu selections and data entry by gently touching the onscreen buttons with a finger or the tip of a soft, non-sharp object such as a pencil eraser.

The Methods Main or Quick Start screens are the primary home for the applications. From those screens you access all the commands needed to operate the PHD ULTRA™ 4400 as well as the main system settings.

The Message Area of the touch screen is used to display helpful instructions for the currently displayed screen. It is also used to display error or warning messages to indicate problem conditions in a Method or error conditions during pump operation.

The software is organized into three main Navigational branches, the quick start operations, preloaded/user-defined Methods, and systems settings. You can control operations directly with the touch screen or remotely from an independent computer or device via the external I/O interface.

Program Description
To operate the PHD ULTRA™ 4400, the user defines all the required parameters for infusing or withdrawing liquids through a Pump Control Method. The basic operation is a simple 4-step procedure:

1. Select a method
2. Enter operating parameters
3. Preview your method
4. Run your method

Applications
• Animal Infusions or Withdrawals - The PHD ULTRA™ 4400 will control the delivery of varying % of nutrients or drugs infused into animals, flush lines using catheters, needles, cannulae or microdialysis.
• Proportioning and Delivering of Mixtures - Mixing gradients or proportions with independent control of two liquids.
• Aerosol for Coating - The pump at high pressure can create an aerosol for the delivery of coating materials such as pharmaceutical tablets and aerosol studies.
• Delivery to Mass Spectroscopy - The delivery of fluids to the MS for calibration, matrix addition or ESI sample.
• Compensating Flows - The continuous infusion and simultaneous withdrawal of liquids for cell cultures or perfusion chambers.
• Dispensers/Injectors — Adhesives, Cell injection, MRI Dyes, Activators/Enzymes, Flow injection, Microreaction vessels, or Stereotaxic delivery.

Advanced GLP Documentation Features:
• Experiment parameter download information to PC
• Alpha/numeric capability

Pump Models
The PHD ULTRA™ 4400 Syringe Pump is available as an Infuse/Withdraw Programmable model. This model supports both infusion and withdrawal operations and can use both simplified pumping profiles or the more advanced pump profiles and I/O settings that permit interactions with external devices. In addition to supporting all of the advanced programming tools available on the PHD ULTRA™ 4400, this model also allows users to create and store multiple user-defined methods on the pump.

Accessories
A full range of accessories are compatible with the PHD ULTRA™ 4400 including syringe heaters, connectors, tubing, syringes and more.
Please follow this link for syringe options.

Please follow this link for tubing and connector options.

Specifications70-3310
Accuracy±0.35%
Reproducibility±0.05%
ClassificationClass I
Dimensions Control Box LxDxH in cm12 x 8.5 x 4.25 (30.48 x 21.59 x 10.80)
Dimensions Remote Box LxDxH in cm11.0 x 5.3 x 7.25 (27.94 x 13.46 x 18.42)
Display4.3" WQVGA TFT Color Display with Touchpad
Drive Motor1.8° Stepper Motor
Environmental Humidity20% to 80% RH, non condensing
Environmental Operating Temperature English40°F to 104°F
Environmental Operating Temperature Metric4°C to 40°C
Environmental Storage Temperatue English14°F to 158°F
Environmental Storage Temperatue Metric-10°C to 70°C
Flow Rate Maximum216 ml/min using 140 ml syringe
Flow Rate Minimum3.06 pl/min using 0.5 µl syringe
I/O & TTL Connectors15 pin D-Sub Connector
Input Power50 W, 0.5 A fuse
Installation CategoryII
Max Linear Force200 lbs @ 100% Force Selection
Mode of OperationContinuous
Motor Drive ControlMicroprocessor with 1/16 microstepping
Net Weight English15.9 lb
Net Weight Metric7.2 kg
No of Syringes1
Non Volatile MemoryStorage of all settings
Number of Microsteps per one rev of Lead Screw6,400
Pollution Degree1
Pump ConfigurationRemote
Pump FunctionInfuse/Withdraw, Programmable
Pusher Travel Rate Maximum190.8 mm/min
Pusher Travel Rate Minimum0.36 µm/min
RS 232 Connectors9 pin D-Sub Connector
Regulatory CertificationsCE, UL, CSA, CB Scheme, EU RoHS
Step Rate Maximum26 µsec/µstep
Step Rate Minimum27.5 sec/µstep
Syringe Rack TypeStandard Rack
Syringe Size Maximum140 ml
Syringe Size Minimum0.5 µl
USB ConnectorsType B
Voltage Range100-240 VAC, 50/60 Hz

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DOCUMENT DESCRIPTION
PHD ULTRA 4400-70-3xxx_5419-004REV1.0.pdfPHD ULTRA 4400 Syringe Pump Series Manual