Non-Invasive Blood Pressure System for Rodents

Non-Invasive Blood Pressure System for Rodents

Easy and reliable technique to measure systemic blood pressure and cardiovascular parameters in rodents without invasive catheterization.

  • Total reliability to realize consecutive measurements on the same animal
  • Analog signal output for recording cuff pressure and pulse signals in a PC
  • Automated deflation driven separately for each animal (minimize tail lesions)
  • Automated cuff inflation/deflation at a very constant rate
  • The same system can be used for mouse/rat/dog
  • Real values provided (without any linear regression calculation)
  • Easily traceable data (using data acquisition software)
  • Parameters evaluated can be visualized on-line on the digital display

 

Item# Description U.S. List Price Quantity
76-0173 Basic Unit for NIBP with RS-232 Serial Port. Cuff and Transducer must be ordered separately. (LE5001)
76-0174 Standard Unit for NIBP with Memory and RS-232 Serial Port. Cuff and Transducer must be ordered separately. (LE5002)
76-0175 Complete Unit for NIBP with Scheduled Data Acquisition (up to 12 Animals) Memory and RS-232 Serial Port. Cuff and Transducer must be ordered separately. (LE5007)
76-0406 (SEDACOMV2.0) SEDACOM Software V2.0
76-0466 Panlab NIBP System Software for the traceability and graphical validation of the 76-0173, 76-0174 or 76-0175 data (NIBPCHART)
76-0608 (CONRS232USB) RS-232/USB Adapter for the SEDACOM software
76-0177 Electronic Rat Simulator (LE5090)
76-0178 Heater for Single Animal (LE5610)
76-0179 Automatic Heater and Scanner for six rats or Six Mice (LE5650-6)
76-0401 Transducer & Holder Fixing Plate (LE5095)
76-0432 Pulse Transducer & Cuff for Mice (Diameter 6 mm) (LE5160-MM)
76-0183 (LE5016) Holder, Mouse (35gr)
76-0184 (LE5018) Holder, Mouse (50gr)
76-0185 (LE5020) Holder, Rat (150gr)
76-0186 (LE5022) Holder, Rat (250gr)
76-0187 (LE5024) Holder, Rat (400gr)
76-0188 (LE5025) Holder, Rat (500gr)
76-0012 Pulse Transducer & Cuff for Mice and Rats up to 150 Grams (LE5160M)
76-0013 Pulse Transducer & Cuff for Rat (LE5160R)
76-0014 Dog Pulse Transducer (18 mm Diameter) (LE5015)
76-0015 Pressure Cuff for Dog Options (LE5012)
76-0016 Set of 100 Spare Membranes for Rat Cuff (MB5160R)
76-0017 Set of 10 Spare Membranes for Mouse Cuff (MB5160M)
76-0018 Mouse Cuff (LE5180M)
76-0019 Rat Cuff (LE5180R)
Login for U.S. Pricing

The Panlab NIPB system provides an easy and reliable technique to measure systemic blood pressure and cardiovascular parameters in rodents without invasive catheterization.

The pulse signal level (heart rate) is continuously monitored on the LCD display while an internal pressure transducer is constantly measuring the current pressure applied on the cuff. Systolic and diastolic blood pressures are displayed after a series of automatic processes finish.

A warm environment is critical for accurate blood pressure measurement. For optimal conditions the Panlab Warming Chamber (76-0178( or the Automatic Heater & Scanner (76-0179) provides a comfortable heated environment. The requirement of a warm environment for the animals is critical for accurate blood pressure measurements. To provide adequate conditions for NIBP measurement, the system can be used in association with a warming chamber which provides a comfortable and heated environment necessary to produce peripheral vasodilatation and isolate the animal from external noise. 

Key Features

  • Total reliability to realize consecutive measurements on the same animal
  • Analog signal output for recording cuff pressure and pulse signals in a PC
  • Automated deflation driven separately for each animal (minimize tail lesions)
  • Automated cuff inflation/deflation at a very constant rate
  • The same system can be used for mouse/rat/dog
  • Real values provided (without any linear regression calculation)
  • Easily traceable data (using data acquisition software)
  • Parameters evaluated can be visualized on-line on the digital display

Parameters Measured

  • Systolic blood pressure
  • Diastolic blood pressure
  • Mean blood pressure
  • Heart rate

Included Components:

Basic Unit for NIBP 76-0173 (LE5001)

  • Control unit with LCD display
  • Pressure and pulse BNC analog signal output
  • RS-232 serial port
  • Cables
  • Spare fuses
  • Instruction manual

Standard Unit for NIBP 76-0174 (LE5002)

  • Includes all components of 76-0173 plus
  • Raw data internal memory (up to 4,000 successive trials)

Complete Unit for NIBP 76-0175 (LE5007)

  • Includes all components of 76-0174 plus
  • Statistical calculations (average, deviation, number of samples for all animals)
  • Connection to the Heater and Scanner device for automatic measurement of up to 12 animals

Accessories

  • SEDACOM Software*
  • Chart™ Software for monitoring of pressure and pulse wave signals
  • Single or multiple animal heating units
  • Pulse Transducer & Cuff*
  • Specimen holders

*Pulse Transducer & Cuff and SeDaCom software must be ordered separately.Requires 76-0608 RS-232/USB adapter.

Specifications
Dimensions LE5001 Control Unit 360 (W) x 340 (D) x 120 (H) mm
Dimensions LE5002 and LE5007 Control Units 60 (W) x 340 (D) x 170 (H) mm
Computer Requirements (only if SeDaCom is used)  PC with Windows™ XP (SP2 or higher), Vista 32, Windows 7 or Windows 8 compatible operating system
Power Supply 220/110 VAC, 50/60 Hz
Certifications CE Compliant

 

Alfany-Fernandez I et al. Therapeutic Targets in Liver Transplantation: Angiotensin II in Nonsteatotic Grafts and Angiotensin-(1–7) in Steatotic Grafts. Am. J. Transplantation. 2009:9(3)-439- 451.

Bhandari U et al. Beneficial effect of Embelia ribes ethanolic extract on blood pressure and glycosylated hemoglobin in streptozotocin-induced diabetes in rats. Fitoterapia. 2008;79(5): 351- 355.

Canicer R et al. Simvastatin reverses the hypertension of heterozygous mice lacking cystathionine α-synthase and apolipoprotein A-I. Naunyn-Schmiedeberg’s Archives of Pharmacology. 2008;377(1):35-43.

Casillas-Ramirez A et al. Inhibition of angiotensin II action protects rat steatotic livers against ischemia-reperfusion injury. Critical Care Medicine. 2008;36(4):1256-1266.

Choi JH et al. Comparative antihypertensive activities of losartan and HM70186 in rats with hepatic dysfunction. Arch. Pharmacal Res. 2009;32(7):1005-1011.

Kim DW et al. (2009) Germinated Buckwheat extract decreases blood pressure and nitrotyrosine immunoreactivity in aortic endothelial cells in spontaneously hypertensive rats. Phytotherapy Research. 2009;23(7):993-998.

Ramalho FS et al. Are Angiotensin II Receptor Antagonists Useful Strategies in Steatotic and Nonsteatotic Livers in Conditions of Partial Hepatectomy under Ischemia-Reperfusion? J. Pharmacol. Exp. Ther. 2009;329:130-140.