Precision Systems for Physiology Research

Our Most Popular Tissue Baths and Perfusion Systems!

Products on this page are for Research Use Only. Not for use in humans unless proper investigational device regulations have been followed.

 
Graz Tissue Bath – Features Low-Volume Tissue Vessels
as Small as 2 ml

Graz Tissue Bath

  • Smooth Muscle, Cardiac Muscle, Skeletal Muscle and Vascular or Tracheal Rings
  • Small Tissue Vessels Allow Experimentation with Expensive or Small Quantity Test Substances
  • Rigid Construction for Measurement of Small Contractile Forces
  • Tissue Holders with Integrated Platinum Field Stimulation Electrodes Available
  • Needle Valves Allow for Accurate and Precise Adjustment of Gas Flow to Each Chamber
  • Click here for more information

Selected References:
Cardiovasc Diabetol. 2009 Dec 30;8:65.
Aminoguanidine inhibits aortic hydrogen peroxide production, VSMC NOX activity and hypercontractility in diabetic mice.
Oak JHYoun JYCai H.
Click here for detailed reference information.

Methods Mol Biol. 2009;573:17-44.
Evaluating micro- and macro-vascular disease, the end stage of atherosclerosis, in rat models.
Russell JC.
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UP-100 Universal Perfusion System: Ideal for Toxicology, Safety Pharmacology, and Drug Screening!

UP100

  • Do you screen drugs through many organs or need a compact, reliable perfusion system for a single application?
  • UP-100 can be used for Heart, Liver, Kidney, Mesenteric Bed and more
  • In Situ or Ex-Vivo perfusion
  • In Situ hind limb perfusion with integrated force measurement for exercise physiology studies, testing muscle relaxants, and testing vasodialative drugs
  • Conduct studies of metabolic processes, compound screening, vascular tone, organ preservation for transplant
  • Click here for more information

Selected References:
Am J Physiol Renal Physiol. 2011 Sep;301(3):F565-73.
Extracellular cAMP-adenosine pathways in the mouse kidney.
Jackson EKRen JCheng DMi Z.
Click here for detailed reference information.

Adv Clin Exp Med. 2008, 17 (3), 269-273
Rat Liver Catalase Protection from a-Amanitin in Extracorporeal Liver Perfusion
Magdalan JChlebda EKwiatkowska J
Click here for detailed reference information.

Exp Physiol., 2009, 90.6, 807-814
Local transfer of prostaglandin E2 into the ovary and its retrograde transfer into the uterus in early pregnant sows
Stefancyk-Krzymowska SChlopek JGrzegorzewski WRadomski M
Click here for detailed reference information.

Endocrinology, 2009, 150(2), 849-861
Endothelial dysfunction in mice with streptozotocin-induced type-1 diabetes is opposed by compensatory overexpression of cyclooxygenase-2 in the vasculature
Nacci CTarquinio MDe Benedictis LMauro A, Zigrino ACarratu MRQuon MMontagnani M
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Isolated Lung System for Mice – Unique Design Minimizes Edema Formation and Lengthens Lung Viability

Isolated Lung System for Mice Isolated Lung System for Mice

  • Minimize Edema Formation with Horizontal In Situ Preparation, Negative Pressure Ventilation, and Constant Pressure Perfusion
  • Do Not Use Rat-Sized Sensors for Mouse Studies: Mouse-Sized Sensors and Cannulae Optimized for Perfused Lung Procedure
  • Perfect for Lung Injury Studies, Testing Nebulized Substances, Resistance & Compliance, Hypoxic/Hypercapnic Studies, and More
  • Also Popular: Ask about our Isolated Lung System for Rats/Guinea Pigs!



Selected References:
Am J Respir Crit Care Med. 2004 Jan 15;169(2):201-8.
Phosphoinositide 3-OH kinase inhibition prevents ventilation-induced lung cell activation.
Uhlig UFehrenbach HLachmann RAGoldmann TLachmann BVollmer EUhlig S.
Click here for detailed reference information.

Eur J Anaesthesiol. 2010 Jan;27(1):61-6.
Effects of ketamine on hypoxic pulmonary vasoconstriction in the isolated perfused lungs of endotoxaemic mice.
Busch CJSpöhr FAMotsch JGebhard MMMartin EOWeimann J.
Click here for detailed reference information.

J Vis Exp. 2011 Apr 29;(50). pii: 2690. doi: 10.3791/2690.
Characterization of the isolated, ventilated, and instrumented mouse lung perfused with pulsatile flow.
Vanderpool RRChesler NC.
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Isolated Heart System for Small Rodents – No High Water Columns – Constant Pressure with a Simple Switch!

Isolated Heart System for Small Rodents

  • Constant Pressure or Constant Flow Perfusion with a simple switch – no high water columns to contribute to large system perfusate volume or aortic valve stress
  • Large thermostated heart chamber easily accommodates a range of specialty sensors (LVP, ECG, Pacing Electrode, Monophasic Action Potential Electrodes)
  • Modular setup – Add functionality any time (cell isolation, electrophysiology, working heart capability, and more)
  • Compact design – no climbing or stepstools required to access any part of the system



  •              Download the Isolated Heart Perfusion System for Small Rodents Guide Here!


Selected References:
FASEB J. 2001 Apr;15(6):1077-9.
Myoglobin facilitates oxygen diffusion.
Merx MWFlögel UStumpe TGödecke ADecking UKSchrader J.
Click here for detailed reference information.

J Am Soc Nephrol. 2005 Nov;16(11):3357-64.
Myocardial stiffness, cardiac remodeling, and diastolic dysfunction in calcification-prone fetuin-A-deficient mice.
Merx MWSchäfer CWestenfeld RBrandenburg VHidajat SWeber CKetteler MJahnen-Dechent W.
Click here for detailed reference information.

Cardiovasc Res., 2010 Aug 1;87(3):485-93.
Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by
structural remodelling.

Reil JCHohl MKazakov AOberhofer MKaestner LMueller PAdam OMaack CLipp PMewis CAllessie MLaufs UBöhm MNeuberger HR
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J Mol Cell Cardiol., 2011 Dec;51(6):906-18.
Effects of DPP-4 inhibition on cardiac metabolism and function in mice.
Lenski MKazakov AMarx NBöhm MLaufs U.
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