MicroVent Ventilator for Prenatal Mice (Model 848) - Single Animal Volume Controlled

MicroVent Ventilator for Prenatal Mice (Model 848) - Single Animal Volume Controlled

The MicroVent Ventilator is a constant-volume respiration pump operating on the Starling principle. Unlike conventional units for larger animals, this ventilator employs a rotary plunger and has no valves. During each ventilation cycle, the plunger performs a synchronized forward and rotating movement. Cleverly arranged bores and channels in the cylinder and plunger control inspiration and expiration during each stroke of the plunger.

• Ideal for very small animals, perinatal mice, birds
• Stroke volume range from 0 to 130 µl
• Ventilation rate from 60 to 400 breaths/minute
• Simple adjustment of stroke volume while running
• Valveless piston pump, no valves to clog
• Very small instrument/circuit dead space volume
• Compact construction, place close to animal
• No vibrations, very low noise .

The extremely light weight and compact construction, in addition to the convenient rod clamp, allow the MicroVent ventilator to be positioned directly next to the animal.

Item# Description U.S. List Price Quantity
73-3591 MICROVENT ULTRALOW VOLUME VENTILATOR TYPE 848, 115 VAC
73-3590 MICROVENT ULTRALOW VOLUME VENTILATOR TYPE 848, 230 VAC
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The MicroVent Ventilator is a constant-volume respiration pump operating on the Starling principle. Unlike conventional units for larger animals, this ventilator employs a rotary plunger and has no valves. During each ventilation cycle, the plunger performs a synchronized forward and rotating movement. Cleverly arranged bores and channels in the cylinder and plunger control inspiration and expiration during each stroke of the plunger.

• Ideal for very small animals, perinatal mice, birds
• Stroke volume range from 0 to 130 µl
• Ventilation rate from 60 to 400 breaths/minute
• Simple adjustment of stroke volume while running
• Valveless piston pump, no valves to clog
• Very small instrument/circuit dead space volume
• Compact construction, place close to animal
• No vibrations, very low noise

The extremely light weight and compact construction, in addition to the convenient rod clamp, allow the MicroVent ventilator to be positioned directly next to the animal. Typical setups with larger ventilators produce large tubing and instrument dead space volumes. These larger volumes introduce greater system compliance which can affect the accuracy with which the full tidal volume is introduced into the animal's lungs. With the MicroVent, the tidal volume error due to system compliance is reduced to less than 3 µl. Tidal volume and respiration rate can be set exactly to the values required for animal ventilation. The level of precision and control available to the investigator minimizes the danger of hyperventilation or hypoventilation. The tidal volume can be varied continuously from 0 to 130 µl during operation without having to interrupt ventilation. The respiration rate is also continuously adjustable from 60 to 400 strokes/min. The expired air can be recovered at the collection port for sampling, recycling or for the generation of a positive end-expiratory pressure (PEEP). Room air or any non-explosive gas mixture can be used to feed the pump intake.

A multi-gas inlet adapter is available for the MicroVent so that alternate gas mixtures and nebulized substances are delivered to the MicroVent inlet port at atmospheric pressure. The adapter provides ports for multiple selectable gas mixtures (hypoxic, anesthetic...) and a port for the Aerosol Nebulizer.

Specifications73-359173-3590
AC Adapter Weight English0.7 lb0.7 lb
AC Adapter Weight Metric0.3 kg0.3 kg
CertificationsCECE
Control ModesVolumeVolume
Depth English7.9 in7.9 in
Depth Metric20 cm20 cm
Displaynonenone
Gas SupplyRoom air or non-flammable mixed gasRoom air or non-flammable mixed gas
Height English3.1 in3.1 in
Height Metric8 cm8 cm
I E Ratio1:11:1
I E Ratio UOM%%
ModelMicroVentMicroVent
Net Weight English2.2 lb2.2 lb
Net Weight Metric1 kg1 kg
Number of Animals11
PEEPProvided via attachment of water columnProvided via attachment of water column
Respiration Rate Maximum400 breaths/min400 breaths/min
Respiration Rate Minimum60 breaths/min60 breaths/min
Respiratory Rate NoteContinuously adjustable from 60 to 400 breaths/minContinuously adjustable from 60 to 400 breaths/min
Sigh Frequencynonenone
Sigh PressureNot availableNot available
SpeciesPerinatal Mice, Small BirdsPerinatal Mice, Small Birds
Stroke Volume NoteContinuously adjustable from 0 to 130 µlContinuously adjustable from 0 to 130 µl
Tidal Volume Maximum0.13 ml/stroke0.13 ml/stroke
Tidal Volume Minimum0.03 ml/stroke0.03 ml/stroke
Voltage Range110 VAC230 VAC
Width English3.9 in3.9 in
Width Metric10 cm10 cm

Anne Hilgendorff , Kakoli Parai , Robert Ertsey , Edwin Navarro , Noopur Jain , Francis Carandang , Joanna Peterson , Lucia Mokres , Carlos Milla , Stefanie Preuss , Miguel Alejandre Alcazar , Suleman Khan , Juliet Masumi , Nancy Ferreira-Tojais , Sana Mujahid , Barry Starcher , Marlene Rabinovitch , Richard Bland (2015 ) Lung matrix and vascular remodeling in mechanically ventilated elastin haploinsufficient newborn mice Am J Physiol Lung Cell Mol Physiol

Sergey A. Sosunov, Xavier Ameer, Zoya V. Niatsetskaya, Irina Utkina-Sosunova, Veniamin I. Ratner, Vadim S. Ten (2015 ) Isoflurane Anesthesia Initiated at the Onset of Reperfusion Attenuates Oxidative and Hypoxic-Ischemic Brain Injury PLoS One

Anne Hilgendorff , Kakoli Parai , Robert Ertsey , G. Juliana Rey-Parra , Bernard Thébaud , Rasa Tamosiuniene , Noopur Jain , Edwin F. Navarro , Barry C. Starcher , Mark R. Nicolls , Marlene Rabinovitch , Richard D. Bland (2012 ) Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth Am J Physiol Lung Cell Mol Physiol

Veniamin Ratner1, Sergey A. Sosunov1, Zoya V. Niatsetskaya1, Irina V. Utkina-Sosunova1, and Vadim S. Ten1 (2013 ) Mechanical Ventilation Causes Pulmonary Mitochondrial Dysfunction and Delayed Alveolarization in Neonatal Mice Am J Respir Cell Mol Biol