IL-2 - Isolated Perfused Rat or Guinea Pig Lung System

IL-2 - Isolated Perfused Rat or Guinea Pig Lung System

Ventilation
The lung is placed in the artificial thoracic chamber and ventilated at negative pressure, it is connected via the tracheal cannula to the pneumotachometer for measurement of respiratory flow. The humidified ventilation medium (air or gas mixture) is constantly flowing past the distal end of the pneumotachometer.

Item# Description U.S. List Price Quantity
73-9905 IL-2 - Isolated Perfused Rat Lung System
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• Optimized in-situ preparation
• Negative-pressure ventilation to mimic more closely the in-vivo situation
• Regular induction of hyperinflation of the lung (sigh, augmented breath)
• Several perfusion modes using buffer solution or blood are available:
– Constant flow perfusion
– Constant pressure perfusion
– Dual perfusion system(constant flow or constant pressure can be selected)
• Continuous measurement of lung mechanics (tidal volume, resistance, compliance), and perfusate
characteristics (pressure, flow, pO2, pCO2, pH)
• Continuous measurement of lung weight (Edema)
Ventilation
The lung is placed in the artificial thoracic chamber and ventilated at negative pressure, it is connected via the tracheal cannula to the pneumotachometer for measurement of respiratory flow. The humidified ventilation medium (air or gas mixture) is constantly flowing past the distal end of the pneumotachometer.
Perfusion
Lungs can be perfused by either constant flow or constant pressure. Although constant flow perfusion may mimic the in vivo situation more closely, it has the disadvantage that hydrostatic edema becomes inevitable during vasoconstriction. Constant pressure perfusion permits higher perfusate flow rates since vasoconstriction decreases perfusate flow and hydrostatic edema is less likely to occur.
Can be configured in one of three different perfusion modes:
1. Constant Flow Perfusion
2. Constant Pressure Perfusion
3. Dual System to Switch from Constant Flow to Constant Pressure and Vice Versa
Lung Weight Changes
Continuous measurement of weight changes of the lung is required for monitoring edema formation. This is possible during negative pressure ventilation inside the thoracic chamber by using the HSE-Edema balance LS 30 (weight transducer) (BS4 73-0593), range
Specifications73-9905
Package1
Product FamilyHugo Sachs Perfusion Systems