IH-5 CORE SYSTEM, BASIC 230 V, 73-4398

IH-5 CORE SYSTEM, BASIC 230 V,  73-4398

IH-5 CORE SYSTEM, BASIC 230 V, 73-4398

Item# Description U.S. List Price Quantity
00-1413 BASIC UNIT FOR ISOLATED HEART SIZE 5 TYPE 843/I 00-1413
73-0125 THERMOSTATIC CIRCULATOR E 103, BATH VOLUME 3 L, 230 V/50 Hz
73-0116 MCP-SB2/230V ROLLER PUMP, 2 CHANNELS, EACH 2-1100 ML/MIN
73-0045 PLUGSYS Case, Type 603
73-3862 APT300 Pressure Transducer for PLUGSYS Module
73-1793 Transducer Amplifier Module (TAM-D)
73-3871 HOLDER FOR APT300 FOR LVP MEASUREMENT FOR IH5
73-0065 Transducer Amplifier Module (TAM-A)
Login for U.S. Pricing

IH-5 LANGENDORFF
The IH-5 utilizes the architecture of the ground-breaking IH-SR to set the standard for isolated heart perfusion in rabbits, adult guinea pigs, or adult rats. Engineered for the increased flow produced by these species (up to 500 mL/min), the IH-5 offers ultimate perfusion stability and real physiological conditions for longer, more relevant recordings with fewer artifacts. This compact platform has been optimized to create in situ-like perfusion features, delivering a considerably higher sensitivity for various experimental manipulation while maintaining the advantages of an ex vivo preparation.

The modular nature of the IH-5 allows the system to evolve along with your research. A Langendorff system can easily be upgraded to full Working Heart (according to Neely); and any IH-5 can be upgraded with a range of measurement capabilities unmatched by any system, like multi-channel ECG and MAP for a complete cardiac electrophysiology workstation.

Other useful add-ons include drug addition (using a syringe pump) and pacing. If perfusate containing albumin or erythrocytes is used, the oxygenation can be optimized with the addition of a fiber oxygenator. The IH-5 utilizes convenient switches that allow the researcher to easily change from constant flow to constant pressure perfusion, Langendorff to Working Heart, and between 2 different perfusion solutions.

The complete system includes virtually everything you need to accomplish the basic Langendorff experiment, only requiring the addition of the appropriate species-specific package, the method of constant pressure perfusion and coronary flow measurement, and the desired data acquisition system. Contact our expert technical team if you need assistance with system configuration, application support or custom design requests.

Includes:
• IH-5 Base Unit for large rodent hearts
(from subjects up to 2.5 kg)
• Thermocirculator
• Analog Roller Pump
• PLUGSYS Basic System Case 603
° Core System Utilizes 4 of 20 total Slot Units
• Perfusion Pressure Measurements
° Pressure Transducer
° TAM-D PLUGSYS Transducer Amplifier Module
• Left Ventricular Pressure Measurement
° Pressure Transducer
° Holder for Pressure Transducer
° TAM-A PLUGSYS Transducer Amplifier Module

Specifications73-004573-386273-179373-0065
Analog IndicationLine Cable, Spare Fuses, Screw driver for fitting Function Modules, Document Folder for Operating Instructions of Function Modules, 3 x BNC-BNC Output linesCETAM-A LED bar graph 20 LEDs (+13/-7) for visual check on the signal sensitivity approx. 1V/LED TAM-D 3 1/2-digit LED displayTAM-A LED bar graph 20 LEDs (+13/-7) for visual check on the signal sensitivity approx. 1V/LED TAM-D 3 1/2-digit LED display
Bridge Balance5.2 x 19 x 17.1 in3 mThrough 10-turn trimmer coarse adjustment and electronic autozero by push button (LED for error if autozero is not possible)Through 10-turn trimmer coarse adjustment and electronic autozero by push button (LED for error if autozero is not possible)
Bridge Supply Voltage132 x 483 x 435 mm2 — 15 V DC (or AC up to 5 kHz)+5V / 50 mA max.+5V / 50 mA max.
Electrical CalibrationMetallic housing, gray plastic coated, Universal 19 inch case with pivoting feet, prepared for rack mounting>1 kHzSelectable by switch on front panel:
a) 0 V output signal with switch in position '0'
b) Positive or negative calibration output voltage adjustable with 10-turn trimmer if switch is in position 'CAL'
Selectable by switch on front panel:
a) 0 V output signal with switch in position '0'
b) Positive or negative calibration output voltage adjustable with 10-turn trimmer if switch is in position 'CAL'
Gain20 slot units max.>5,000 VSelectable ranges by internal Jumper: 0.2 to 10, 0.4 to 20, 1 to 50, 2 to 100, 4 to 200, 10 to 500, 20 to 1000, 100 to 5000, 200 to 10000. Fine Adjustment Through 10-Turn TrimmerSelectable ranges by internal Jumper: 0.2 to 10, 0.4 to 20, 1 to 50, 2 to 100, 4 to 200, 10 to 500, 20 to 1000, 100 to 5000, 200 to 10000. Fine Adjustment Through 10-Turn Trimmer
Output Low-Pass Filter100 to 240 VAC, 50/60 Hz, built-in line filter, 100 W max. consumption–300 to 300 mmHga) Selectable by switch on front panel for pulsatile output signal: 1, 100, 300 Hz
b) Selectable by internal jumper for mean output signal: 0.1, 0.3 Hz
a) Selectable by switch on front panel for pulsatile output signal: 1, 100, 300 Hz
b) Selectable by internal jumper for mean output signal: 0.1, 0.3 Hz
PLUGSYS Width*3-pin IEC mains with fuse and mains switch on back of housing15 to 40 °C2 slot units2 slot units
Power Supply14.3 lbs356 ± 1% Ω+5V through connector from PLUGSYS bus system+5V through connector from PLUGSYS bus system
Signal Output6.5 kg4,000 mmHga) On front panel through BNC socket a) On front panel through BNC socket
Transducer Input± 300 mmHg6-pin socket with screw lock (binder, Amphenol Tuchel) Differential input circuit, imput impedance 1010?6-pin socket with screw lock (binder, Amphenol Tuchel) Differential input circuit, imput impedance 1010?
5 µV/V/mmHg
–25 to 70 °C
PLUGSYS
< 1% /°C
< 0.04 mmˆ3/100 mmHg
< 0.2 mmHg/°C
<25 mmHg
<25 mmHg

Features and Benefits

 

  • Compact design, optimized individually for: rabbit, rat or guinea pig
  • Constant pressure or constant flow perfusion in one unit, easily switch between the two modes
  • Compact, doesn’t require wall installed high water columns, suitable for hearts from hypertensive animals (perfusion pressures up to 300 mmHg are possible)
  • Unique integrated small volume aortic block with built-in bubble trap and compliance chamber
  • Unique cannulae design

- Cannula resistance is optimized according to Hagen-Poiseuilles Physical Law
- Different cannula sizes available, all metal, no fragile glass cannulae

  • Proprietary mini holders allow easy and stress-free access to hold electrodes and catheters in position
  • Drug injection pathway built directly into aortic perfusate stream
  • Easily upgraded to a Working Heart System

 

PARAMETERS ON AN IH-5 BASIC SYSTEM:
The following signals are recorded as raw data:

  • Isovolumetric Left Ventricular Pressure (Balloon Method)
  • Aortic (Perfusion) Pressure
  • Coronary Flow*


The following parameters are calculated from the raw data (using a DAQ System):

  • dLVP/dt, dLVP/dt Max, dLVP/dt Min, Contractility Index
  • Systolic and Diastolic LVP
  • Heart Rate
  • Mean Perfusion Pressure
  • Mean Perfusion Flow*
  • Coronary Resistance*

* This Parameter is based on Indirect Flow Measurement with Option SCP or Direct Flow Measurement with IH5-STARLING and IH5-DIRECT added to the core system.