Computer Controlled Multi-Clamp with Data Acquisition and Analysis Software

Computer Controlled Multi-Clamp with Data Acquisition and Analysis Software

This unique package integrates the amplifiers, data acquisition system, and analysis software all into one convenient box! The system provides individual data acquisition and control for 2, 4 or 6 chambers and is fully compatible with the NaviCyte horizontal/vertical diffusion chamber systems. Windows 10/7/XP compatible.

  • Microcomputer controlled current/voltage clamp
  • Individual data acquisition from and control of 2, 4 or 6 chambers
  • Works with Harvard/NaviCyte horizontal or vertical diffusion chambers
  • PC to Multi-Clamp interface is through standard serial COM port connection (no additional cards are needed)
  • Windows 10 or earlier compatible software

Item# Description U.S. List Price Quantity
69-0300 2-Channel Voltage/Current Clamp System with Software
69-0301 4-Channel Voltage/Current Clamp System with Software
69-0302 6-Channel Voltage/Current Clamp System with Software
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 The Computer Controlled Multi-Clamp with Software is a voltage/current clamp and data acquisition system in one compact microcomputer controlled unit. In its full configuration it can be used to control and collect electrophysiological data from up to six horizontal or vertical Ussing chambers. The system is fully compatible with all systems from Warner, including our NaviCyte offering.

The system provides independent chamber control in three different modes: voltage clamp, current clamp, and open circuit modes. A change between any of these modes is available at every time point during acquisition.

The Multi-Clamp is available in 2-, 4- or 6-channel configurations. The clamp provides a separate A/D converter and isolated current source for each chamber, and current and voltage electrodes from each half-cell are connected to the Multi-Clamp via an electrode manifold. Data exchange between the PC and the Multi-Clamp is via standard COM ports, and depending on the number of ports available, a single PC can handle several clamps.

An interesting option consists of the incorporation of a gas delivery system into a NaviCyte/Multi-Clamp system. This gas delivery system consists of 12 precision gas flow meters mounted to a stabilizing base and connect to a 6-channel NaviCyte vertical or horizontal chamber systems. The 600x400 mm stabilizing base also houses an electrode manifold for connecting each Ag/AgCl electrodes to their respective half-cells.

Software

The Multi-Clamp system comes complete with an easy to use Windows (XP or earlier) based control and data acquisition software package that allows for the individual control and monitoring of each chamber.

    Some features of the software include:
  • Automatic compensation of fluid resistance and electrode potential during the experiment
  • Individual voltage clamp, current clamp or open circuit control for each chamber
  • Overlay of uni/bipolar current pulses with variable parameters for dynamic definition of Gt/Rt
  • I/V and V/I curves with freely adjustable parameters
  • Minimum pulse duration 200 ms, max. amplitude ±250 µA for dynamic definition of Gt/Rt
  • Alphanumeric display of measured parameters
  • Ability to input marker and comments and save with data file
  • Printout of parameters in variable timetable
  • Data format compatible to Excel
  • Continuous graphics display
  • Experimental time up to 8 hours
Specifications
Channels 2, 4 or 6
A/D Subsystem for Analog Data Acquisition 13 Bit
Current Source by D/A 12 Bit, isolated
Serial Connection to PC COM1/2 for bi-directional data transfer
Case Dimensions 24.5 x 11.4 x 19.7 cm
(9.6 x 4.5 x 7.8 in)
Power 100/230 VAC, 50/60 Hz
Input Resistance > 109 Ω differential
Input Current < 100 pA
Input Voltage ±400 mV, 0.1 mV step
Current Output ±2000 µA, 1 µA step
Product of Current and External Resistance Max 13 V
  1. Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium,
    Bikramjit Chopra, Stacey R. Barrick, Susan Meyers, Jonathan M. Beckel, Mark L. Zeidel, Anthony P. D. W. Ford, William C. de Groat, Lori A. Birder,
    The Journal of Physiology Volume 562 Issue 3 Page 859-871, February 2005
DOCUMENT DESCRIPTION
Warner's Guide to Ussing Chamber Systems (091022) WLR.pdfWarner's Guide to Ussing Chamber Systems