Bilayer Channel Simulators (CM-3, CM-1)

Bilayer Channel Simulators (CM-3, CM-1)

The CM-1 and CM-3 Single Channel Simulators are designed to simulating a gating ion channel. These novel tools allow you to train on data analysis and to test your system's performance.
 
The CM-1 has unvarying channel characteristics while the CM-3 can be continuously varied.

Features of the CM-3 include

  • Individual selection of open and close time constants via calibrated rotary dial. These settings will uniquely determine channel open probability according to well-known biophysical relationships.
  • Selection of unitary channel conductance via calibrated rotary dial.
  • Available in two membrane capacitances, 10 and 100 pF.
  • Small dimensions allow easy attachment to the amplifier headstage within the Faraday cage enclosure.
  • Operates on 9 volt transistor battery.

Item# Description U.S. List Price Quantity
64-0024 CM-1/10 Single Channel Simulator with 10 pF Membrane
64-0025 CM-1/100 Single Channel Simulator with 100 pF Membrane
64-0026 CM-3/10 Single Channel Variable Simulator with 10 pF Membrane
64-0027 CM-3/100 Single Channel Variable Simulator with 100 pF Membrane
64-1618 (CM-CABLE) Cable, adapts CM-1 and CM-3 simulators to non-Warner amplifiers
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The CM-1 is a single channel model with fixed characteristics which simulates an actively gating ion channel.

Gating transitions from the closed to the open, or from the open to the closed state are randomly induced within the constraints imposed by the factory determined mean open and mean close time settings (10 ms).

A choice of two unitary conductances are available (20 or 200 pS). The patch model has a conductance of 20 pS and a capacitance of 10 pF. The bilayer model has a conductance of 20o pS and a capacitance of 100 pF.

For non-Warner amplifiers a special adapter, the CM-Cable, is required for operation.

The CM-3 is a continuously variable single channel model which simulates an actively gating ion channel. Gating transitions from the closed to the open, or from the open to the closed state are randomly induced within the constraints imposed by the mean open and mean close time settings.

This unique device provides the researcher with a means to generate well-defined ion channel gating kinetics allowing critical analysis of data acquisition hardware and software, data analysis software, and can be used as a teaching aid.

For non-Warner amplifiers a special adapter, the CM-Cable, is required for operation.

Specifications
CM-1
Model CM-1
Mean Time Constants Open and closed factory set to 10 ms
Conductance 20 and 200 pS for patch and bilayer models, respectively
Battery 3 V lithium, 3 years of continuous operation
Dimensions, H x W x D 2.8 x 5.7 x 2.2 cm (7.1 x 14.5 x 5.6 in)


CM-3
Model CM-3
Mean Time Constants Individually adjustable from 1-200 ms
Conductance Continuously variable from 0-750 pS
Battery 9 V, 3 years of continuous operation
Dimensions, H x W x D 6.6 x 7.6 x 4.2 cm (16.8 x 19.3 x 10.7 in)
DOCUMENT DESCRIPTION
Warner Bilayer Workstation brochure (rev 060601).pdfWarner Bilayer Workstation Brochure
CM-3 (1999.07.05).pdfCM-3 User's Guide
CM-Cable (070823).pdfCM-Cable Manual